KEGG   DRUG: TalinololHelp
Entry
D07184                      Drug                                   

Name
Talinolol (INN)
Formula
C20H33N3O3
Exact mass
363.2522
Mol weight
363.4943
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
Transporter substrate
 DG01665  P-glycoprotein substrate
Remark
ATC code: 
Activity
Antiarrhythmic, beta1-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB1 [HSA:153] [KO:K04141]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB13 Talinolol
      D07184  Talinolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Talinolol
      D07184  Talinolol (INN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  ABCB1
   Talinolol
    D07184  Talinolol (INN)
BRITE hierarchy
Other DBs
CAS: 
57460-41-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   O2a O    20.5100  -24.0800
            2   C1b C    21.7000  -23.3800
            3   C1c C    22.9600  -24.0800
            4   C1b C    24.1500  -23.3800
            5   N1b N    25.3400  -24.0800
            6   C1d C    26.6000  -23.3800
            7   O1a O    22.9600  -25.4800
            8   C1a C    27.8007  -24.0999
            9   C1a C    26.6231  -21.9802
            10  C1a C    27.8124  -22.6800
            11  C8y C    20.5272  -25.4799
            12  C8x C    19.3108  -26.2024
            13  C8x C    19.3281  -27.6023
            14  C8y C    20.5491  -28.2873
            15  C8x C    21.7656  -27.5647
            16  C8x C    21.7482  -26.1648
            17  N1b N    20.5665  -29.6799
            18  C5a C    19.3729  -30.3891
            19  N1b N    18.1610  -29.7094
            20  C1y C    16.9481  -30.4304
            21  O5a O    19.3903  -31.7800
            22  C1x C    15.7292  -29.7471
            23  C1x C    14.5258  -30.4625
            24  C1x C    14.5435  -31.8623
            25  C1x C    15.7624  -32.5456
            26  C1x C    16.9658  -31.8302
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     3   7 1
            7     6   8 1
            8     6   9 1
            9     6  10 1
            10    1  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   14  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   18  21 2
            22   20  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   20  26 1

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