KEGG   DRUG: EtofibrateHelp
Entry
D07187                      Drug                                   

Name
Etofibrate (INN)
Formula
C18H18ClNO5
Exact mass
363.0874
Mol weight
363.7922
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01946  Hypolipidemic agent
  DG01547  Fibrates
Other
 DG01733  PPAR agonist
  DG01547  Fibrates
Remark
ATC code: 
Activity
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist
Comment
Clofibrate derivative
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
  Pathway
PPAR signaling pathway
Adipocytokine signaling pathway
Interaction
Drug interaction
Structure map
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AB Fibrates
     C10AB09 Etofibrate
      D07187  Etofibrate (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) alpha
     Etofibrate
      D07187  Etofibrate (INN)
BRITE hierarchy
Other DBs
CAS: 
31637-97-5
PubChem: 
ChEMBL: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8x C    10.5700  -19.2500
            2   C8y C    10.5700  -20.6500
            3   C8x C    11.7824  -21.3500
            4   C8x C    12.9949  -20.6500
            5   C8y C    12.9949  -19.2500
            6   C8x C    11.7824  -18.5500
            7   O2a O    14.2324  -18.5500
            8   C1d C    15.4449  -19.2500
            9   C7a C    16.6573  -18.5500
            10  O7a O    17.8697  -19.2500
            11  C1b C    19.0822  -18.5500
            12  C1b C    20.2946  -19.2500
            13  O7a O    21.5070  -18.5500
            14  C7a C    22.7195  -19.2500
            15  C8y C    23.9319  -18.5500
            16  C8x C    25.1504  -19.2535
            17  C8x C    26.3628  -18.5535
            18  C8x C    26.3629  -17.1535
            19  N5x N    25.1444  -16.4500
            20  C8x C    23.9319  -17.1500
            21  O6a O    16.6573  -17.1500
            22  O6a O    22.7195  -20.6497
            23  C1a C    14.9549  -20.5324
            24  C1a C    16.1449  -20.4624
            25  X   Cl    9.3576  -21.3500
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   15  20 1
            22    9  21 2
            23   14  22 2
            24    8  23 1
            25    8  24 1
            26    2  25 1

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