KEGG   DRUG: D07227Help
Entry
D07227                      Drug                                   

Name
Ornipressin (INN);
POR 8 Sandoz (TN)
Formula
C45H63N13O12S2
Exact mass
1041.4161
Mol weight
1042.1916
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasoconstrictor
Remark
ATC code: 
Target
arginine vasopressin receptor 1A (AVPR1A) agonist [HSA:552] [KO:K04226];
arginine vasopressin receptor 1B (AVPR1B) agonist [HSA:553] [KO:K04227];
arginine vasopressin receptor 2 (AVPR2) agonist [HSA:554] [KO:K04228]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04962  Vasopressin-regulated water reabsorption  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01B POSTERIOR PITUITARY LOBE HORMONES
    H01BA Vasopressin and analogues
     H01BA05 Ornipressin
      D07227  Ornipressin (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Vasopressin
    arginine vasopressin receptor 1A (AVPR1A)
     Ornipressin
      D07227  Ornipressin (INN)
    arginine vasopressin receptor 1B (AVPR1B)
     Ornipressin
      D07227  Ornipressin (INN)
    arginine vasopressin receptor 2 (AVPR2)
     Ornipressin
      D07227  Ornipressin (INN)
BRITE hierarchy
Other DBs
CAS: 
3397-23-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        72
            1   N1y N    19.8125  -21.0028
            2   C1y C    20.2326  -22.2629
            3   C5a C    19.8125  -19.6725
            4   C1x C    18.4824  -21.0028
            5   C5a C    21.3528  -22.8930
            6   C1x C    19.1125  -23.0329
            7   C1y C    20.9326  -19.0424
            8   O5a O    18.6224  -19.0424
            9   C1x C    18.0623  -22.2629
            10  N1b N    22.4729  -22.2629
            11  O5a O    21.3528  -24.2231
            12  N1x N    20.9326  -17.7123
            13  C1x C    22.0528  -19.6725
            14  C1c C    23.6630  -22.8930
            15  C5x C    22.0528  -17.0122
            16  S3x S    23.1729  -19.0424
            17  C5a C    23.6630  -24.2231
            18  C1b C    24.7831  -22.2629
            19  C1y C    22.0528  -15.6820
            20  O5x O    23.1729  -17.7123
            21  S3x S    24.3632  -19.6725
            22  N1b N    24.7831  -24.8532
            23  O5a O    22.4729  -24.8532
            24  C1b C    25.9033  -22.8930
            25  N1x N    20.9326  -15.0520
            26  C1b C    23.1729  -15.0520
            27  C1x C    25.4833  -19.0424
            28  C1b C    25.9033  -24.2231
            29  C1b C    27.0234  -22.2629
            30  C5x C    20.9326  -13.7218
            31  C1y C    26.6035  -19.6725
            32  C1y C    22.9630  -13.0217
            33  O5x O    19.8125  -13.0917
            34  C5x C    27.7935  -19.0424
            35  N1x N    24.7831  -13.7218
            36  C1b C    22.9630  -11.2715
            37  N1x N    28.9137  -19.6725
            38  O5x O    27.7935  -17.7123
            39  C5x C    26.6734  -13.0217
            40  C1b C    21.8429  -10.6414
            41  C1y C    30.0338  -19.0424
            42  C1y C    28.9137  -13.7218
            43  O5x O    26.6734  -11.6916
            44  C5a C    20.6527  -11.2715
            45  C1b C    31.1540  -19.6725
            46  C5x C    30.0338  -17.4322
            47  C1b C    30.1739  -13.0917
            48  N1x N    28.9137  -16.7321
            49  N1a N    19.5325  -10.5714
            50  O5a O    20.6527  -12.6016
            51  C8y C    32.3441  -19.0424
            52  O5x O    31.1540  -16.7321
            53  C8y C    31.3640  -13.6518
            54  C8x C    33.4643  -19.6725
            55  C8x C    32.3441  -17.7123
            56  C8x C    31.3640  -14.9819
            57  C8x C    32.5541  -13.0217
            58  C8x C    34.5845  -19.0424
            59  C8x C    33.4643  -17.0122
            60  C8x C    32.5541  -15.6820
            61  C8x C    33.6743  -13.6518
            62  C8y C    34.5845  -17.7123
            63  C8x C    33.6743  -14.9819
            64  O1a O    35.7746  -17.0122
            65  C5a C    27.0934  -24.9232
            66  N1a N    28.3537  -24.2231
            67  O5a O    27.0934  -26.3234
            68  N1a N    28.2137  -22.8930
            69  N1a N    26.6035  -21.0727
            70  C5a C    24.3784  -15.7421
            71  N1a N    25.5512  -15.0592
            72  O5a O    24.3841  -17.1544
BOND        75
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1 #Down
            5     2   6 1
            6     7   3 1 #Up
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    7  12 1
            12    7  13 1
            13   10  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1 #Up
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   16  21 1
            21   17  22 1
            22   17  23 2
            23   18  24 1
            24   19  25 1
            25   19  26 1 #Up
            26   21  27 1
            27   22  28 1
            28   24  29 1
            29   25  30 1
            30   27  31 1
            31   30  32 1
            32   30  33 2
            33   31  34 1
            34   32  35 1
            35   32  36 1 #Down
            36   34  37 1
            37   34  38 2
            38   35  39 1
            39   36  40 1
            40   37  41 1
            41   39  42 1
            42   39  43 2
            43   40  44 1
            44   41  45 1 #Down
            45   41  46 1
            46   42  47 1 #Up
            47   42  48 1
            48   44  49 1
            49   44  50 2
            50   45  51 1
            51   46  52 2
            52   47  53 1
            53   51  54 2
            54   51  55 1
            55   53  56 2
            56   53  57 1
            57   54  58 1
            58   55  59 2
            59   56  60 1
            60   57  61 2
            61   58  62 2
            62   60  63 2
            63   62  64 1
            64    6   9 1
            65   46  48 1
            66   59  62 1
            67   61  63 1
            68   28  65 1
            69   65  66 1
            70   65  67 2
            71   29  68 1
            72   31  69 1 #Up
            73   26  70 1
            74   70  71 1
            75   70  72 2

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