KEGG   DRUG: D07231Help
Entry
D07231                      Drug                                   

Name
Methylthiouracil (INN);
Thimecil (TN)
Formula
C5H6N2OS
Exact mass
142.0201
Mol weight
142.1789
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antithyroid
Remark
Same as: 
ATC code: 
Target
thyroid peroxidase inhibitor [HSA:7173] [KO:K00431];
deiodinase, iodothyronine, type I inhibitor [HSA:1733] [KO:K01562];
deiodinase, iodothyronine, type II inhibitor [HSA:1734] [KO:K17904]
  Pathway
hsa00350  Tyrosine metabolism
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05320  Autoimmune thyroid disease  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03B ANTITHYROID PREPARATIONS
    H03BA Thiouracils
     H03BA01 Methylthiouracil
      D07231  Methylthiouracil (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   thyroid peroxidase
    Methylthiouracil
     D07231  Methylthiouracil (INN)
   type I iodothyronine deiodinase
    Methylthiouracil
     D07231  Methylthiouracil (INN)
   type II iodothyronine deiodinase
    Methylthiouracil
     D07231  Methylthiouracil (INN)
BRITE hierarchy
Other DBs
CAS: 
56-04-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        9
            1   C8y C    28.0700  -19.8100
            2   N4x N    28.0700  -18.4100
            3   C8y C    26.8800  -17.7100
            4   C8x C    25.6900  -18.4100
            5   C8y C    25.6900  -19.8100
            6   N4x N    26.8800  -20.5100
            7   S0  S    29.3300  -20.5100
            8   O5x O    26.8800  -16.3100
            9   C1a C    24.4300  -20.5100
BOND        9
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     1   7 2
            8     3   8 2
            9     5   9 1

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