KEGG   DRUG: D07283Help
Entry
D07283                      Drug                                   

Name
Esketamine (INN)
Formula
C13H16ClNO
Exact mass
237.092
Mol weight
237.7252
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic
Remark
ATC code: 
Target
N-methyl-D-aspartate receptor antagonist [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse  
 
Interaction
Drug interaction
Structure map
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AX Other general anesthetics
     N01AX14 Esketamine
      D07283  Esketamine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Esketamine
      D07283  Esketamine (INN)
BRITE hierarchy
Other DBs
CAS: 
33643-46-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C1z C    19.3775  -16.0455
            2   C8y C    18.1910  -16.7434
            3   C5x C    20.7733  -16.0455
            4   C1x C    18.6796  -14.8590
            5   N1b N    20.0754  -17.2319
            6   C8y C    16.9348  -16.0455
            7   C8x C    18.1910  -18.1392
            8   C1x C    21.4712  -14.7892
            9   O5x O    21.4712  -17.2319
            10  C1x C    19.3775  -13.6028
            11  C1a C    19.3775  -18.4882
            12  C8x C    15.7483  -16.7434
            13  X   Cl   16.9348  -14.6496
            14  C8x C    16.9348  -18.8371
            15  C1x C    20.7733  -13.6028
            16  C8x C    15.7483  -18.1392
BOND        17
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   12  16 2
            16   10  15 1
            17   14  16 1

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