KEGG   DRUG: BambuterolHelp
Entry
D07377                      Drug                                   

Name
Bambuterol (INN)
Formula
C18H29N3O5
Exact mass
367.2107
Mol weight
367.44
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
Remark
ATC code: 
Chemical group: 
Activity
Bronchodilator, beta2-Adrenergic receptor agonist
Comment
Phenethylamine derivative
long-acting beta-adrenoceptor agonist (LABA)
Active form of prodrug: Terbutaline [DR:D08570]
Target
ADRB2 [HSA:154] [KO:K04142]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CC Selective beta-2-adrenoreceptor agonists
     R03CC12 Bambuterol
      D07377  Bambuterol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta2-adrenergic receptor
     Bambuterol
      D07377  Bambuterol (INN)
BRITE hierarchy
Other DBs
CAS: 
81732-65-2
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8x C    16.8331  -16.5489
            2   C8y C    16.8331  -17.9514
            3   C8x C    18.0477  -18.6527
            4   C8y C    19.2625  -17.9514
            5   C8x C    19.2625  -16.5489
            6   C8y C    18.0477  -15.8476
            7   C1c C    20.5023  -18.6527
            8   C1b C    21.7170  -17.9514
            9   N1b N    22.9316  -18.6527
            10  O7a O    15.6185  -18.6527
            11  C7a C    14.4037  -17.9514
            12  N1c N    13.1891  -18.6527
            13  C1a C    11.9745  -17.9514
            14  O6a O    14.4037  -16.5491
            15  C1a C    13.1891  -20.0553
            16  O1a O    20.5085  -20.0550
            17  O7a O    18.0477  -14.4452
            18  C7a C    16.8163  -13.7341
            19  N1c N    15.6102  -14.4304
            20  C1a C    14.4249  -13.7460
            21  C1a C    15.6096  -15.7771
            22  O6a O    16.8165  -12.3412
            23  C1d C    24.1797  -17.9327
            24  C1a C    25.3641  -18.6171
            25  C1a C    24.1804  -16.5203
            26  C1a C    25.3921  -17.2327
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    2  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   11  14 2
            15   12  15 1
            16    7  16 1
            17    6  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   19  21 1
            22   18  22 2
            23    9  23 1
            24   23  24 1
            25   23  25 1
            26   23  26 1

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