| Entry |
|
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| Name |
Chlorphenamine (INN);
Chlorpheniramine;
Clofeniramina (TN)
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| Formula |
C16H19ClN2
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| Exact mass |
274.1237
|
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| Mol weight |
274.7885
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| Structure |
     |
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| Activity |
Antiallergic;
Histamine, H1-receptor antagonist
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| Remark |
|
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| Target |
|
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| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
|
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| Structure map |
| Histamine H1 receptor antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AB Substituted alkylamines
R06AB04 Chlorphenamine
D07398 Chlorphenamine (INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
H1-receptor [HSA:3269] [KO:K04149]
Chlorphenamine [ATC:R06AB04]
D07398 Chlorphenamine (INN)
 |
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| Other DBs |
CAS: 132-22-9 PubChem: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 19
1 C8x C 13.8600 -15.8900
2 C8y C 13.8600 -17.2900
3 C8x C 15.0724 -17.9900
4 C8x C 16.2849 -17.2900
5 C8y C 16.2849 -15.8900
6 C8x C 15.0724 -15.1900
7 C1c C 17.5160 -15.1790
8 C8y C 18.7212 -15.8747
9 C8x C 18.7216 -17.2896
10 C8x C 19.9342 -17.9893
11 C8x C 21.1465 -17.2889
12 C8x C 21.1460 -15.8739
13 N5x N 19.9334 -15.1743
14 C1b C 17.5157 -13.7901
15 C1b C 18.7281 -13.0901
16 N1c N 18.7281 -11.6901
17 C1a C 19.9643 -10.9760
18 C1a C 17.5397 -11.0038
19 X Cl 12.6476 -17.9900
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 7 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 16 18 1
20 2 19 1
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