KEGG   DRUG: AmantadineHelp
Entry
D07441                      Drug                                   

Name
Amantadine (INN)
Formula
C10H17N
Exact mass
151.1361
Mol weight
151.2487
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antiviral
 DG02841  Viral uncoating inhibitor
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
 DG01967  Antiparkinson agent
Remark
Same as: C06818
ATC code: N04BB01
Chemical structure group: DG00860
Product (DG00860): D00777<JP/US>
Efficacy
Antiviral, M2 protein inhibitor, Antiparkinsonian, Dopamine secretagogue
Comment
Adamantane derivative
Target
Influenza A virus M2 proton channel [KO:K19394]
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
ko05164  Influenza A
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
map07044  Antiviral agents
map07057  Antiparkinsonian agents
map07235  N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BB Adamantane derivatives
     N04BB01 Amantadine
      D07441  Amantadine (INN)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Antiparkinson Agents, Other
   Amantadine
    D07441  Amantadine (INN)
 Antivirals
  Anti-influenza Agents
   Amantadine
    D07441  Amantadine (INN)
BRITE hierarchy
Other DBs
CAS: 768-94-5
PubChem: 51091772
ChEBI: 2618
ChEMBL: CHEMBL19601 CHEMBL660
DrugBank: DB00915
PDB-CCD: 308[PDBj]
LigandBox: D07441
NIKKAJI: J6.971J
KCF data Show

ATOM        11
            1   C1z C    24.7800  -16.7300
            2   C1x C    23.7300  -17.3600
            3   C1x C    24.1500  -18.2000
            4   C1x C    25.8300  -17.3600
            5   N1a N    24.7800  -15.5400
            6   C1y C    23.7300  -18.5500
            7   C1y C    24.1500  -19.3200
            8   C1y C    25.8300  -18.5500
            9   C1x C    22.4700  -19.8100
            10  C1x C    24.7800  -19.1800
            11  C1x C    25.3400  -20.3700
BOND        13
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     6   9 1
            9     6  10 1
            10    7  11 1
            11    7   9 1
            12    8  10 1
            13    8  11 1

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