KEGG   DRUG: D07441Help
Entry
D07441                      Drug                                   

Name
Amantadine (INN)
Formula
C10H17N
Exact mass
151.1361
Mol weight
151.2487
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral, Antiparkinsonian [DS:H00057 H00398]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Indications: Influenza, Parkinsonism
Adamantane derivative
Target
influenza A M2 proton channel blocker [VG:NC_004907_1 NC_002016_1 NC_007367_1 NC_007377_1 NC_007363_1];
N-methyl-D-aspartate receptor antagonist [HSA:2902 2903 2904] [KO:K05208 K05209 K05210]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse  
 
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
Antiviral agents
Antiparkinsonian agents
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BB Adamantane derivatives
     N04BB01 Amantadine
      D07441  Amantadine (INN)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Antiparkinson Agents, Other
   Amantadine
    D07441  Amantadine (INN)
 Antivirals
  Anti-influenza Agents
   Amantadine
    D07441  Amantadine (INN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-influenza agents
   Uncoating inhibitor
    influenza A M2 proton channel blocker
     Amantadine
      D07441  Amantadine (INN)
BRITE hierarchy
Other DBs
CAS: 
768-94-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        11
            1   C1z C    24.7800  -16.7300
            2   C1x C    23.7300  -17.3600
            3   C1x C    24.1500  -18.2000
            4   C1x C    25.8300  -17.3600
            5   N1a N    24.7800  -15.5400
            6   C1y C    23.7300  -18.5500
            7   C1y C    24.1500  -19.3200
            8   C1y C    25.8300  -18.5500
            9   C1x C    22.4700  -19.8100
            10  C1x C    24.7800  -19.1800
            11  C1x C    25.3400  -20.3700
BOND        13
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     6   9 1
            9     6  10 1
            10    7  11 1
            11    7   9 1
            12    8  10 1
            13    8  11 1

» Japanese version   » Back

DBGET integrated database retrieval system