KEGG   DRUG: AmantadineHelp
Entry
D07441                      Drug                                   

Name
Amantadine (INN)
Formula
C10H17N
Exact mass
151.1361
Mol weight
151.2487
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
 DG01967  Antiparkinson agent
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antiviral, M2 protein inhibitor, Antiparkinsonian, Dopamine secretagogue
Comment
Indications: Influenza, Parkinsonism
Adamantane derivative
Target
influenza A M2 proton channel [VG:1461002 956528 3655153 3655107 3654621];
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Long-term potentiation
Glutamatergic synapse
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
Antiviral agents
Antiparkinsonian agents
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BB Adamantane derivatives
     N04BB01 Amantadine
      D07441  Amantadine (INN)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Antiparkinson Agents, Other
   Amantadine
    D07441  Amantadine (INN)
 Antivirals
  Anti-influenza Agents
   Amantadine
    D07441  Amantadine (INN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-influenza agents
   Uncoating inhibitor
    influenza A M2 proton channel blocker
     Amantadine
      D07441  Amantadine (INN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLC22A2
   Amantadine
    D07441  Amantadine (INN)
BRITE hierarchy
Other DBs
CAS: 
768-94-5
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        11
            1   C1z C    24.7800  -16.7300
            2   C1x C    23.7300  -17.3600
            3   C1x C    24.1500  -18.2000
            4   C1x C    25.8300  -17.3600
            5   N1a N    24.7800  -15.5400
            6   C1y C    23.7300  -18.5500
            7   C1y C    24.1500  -19.3200
            8   C1y C    25.8300  -18.5500
            9   C1x C    22.4700  -19.8100
            10  C1x C    24.7800  -19.1800
            11  C1x C    25.3400  -20.3700
BOND        13
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     6   9 1
            9     6  10 1
            10    7  11 1
            11    7   9 1
            12    8  10 1
            13    8  11 1

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