KEGG   DRUG: D07447Help
Entry
D07447                      Drug                                   

Name
Amiloride (INN);
Amiclaran (TN)
Formula
C6H8ClN7O
Exact mass
229.0479
Mol weight
229.627
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic, potassium-sparing
Remark
Same as: 
ATC code: 
Drug group: 
Target
Epithelial sodium channel (SCNN) blocker [HSA:6337 6338 6340] [KO:K04824 K04825 K04827]
  Pathway
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03D POTASSIUM-SPARING AGENTS
    C03DB Other potassium-sparing agents
     C03DB01 Amiloride
      D07447  Amiloride (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Potassium-sparing
   Amiloride
    D07447  Amiloride (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Epithelial and related channels
   Epithelial sodium channel (SCNN)
    renal epithelial Na+ channel (SCNN)
     Amiloride
      D07447  Amiloride (INN)
BRITE hierarchy
Other DBs
CAS: 
2609-46-3
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   C8y C    23.5900  -17.9200
            2   C5a C    24.7800  -18.6200
            3   C8y C    23.5900  -16.5200
            4   N5x N    22.3300  -18.6200
            5   N1b N    25.9700  -17.9200
            6   O5a O    24.7800  -20.0200
            7   N5x N    22.3300  -15.8200
            8   N1a N    24.7800  -15.8200
            9   C8y C    21.1400  -17.9200
            10  C2c C    27.1600  -18.6200
            11  C8y C    21.1400  -16.5200
            12  X   Cl   19.9500  -18.6200
            13  N1a N    28.4200  -17.9200
            14  N2a N    27.1600  -20.0200
            15  N1a N    19.9500  -15.8200
BOND        15
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    7  11 1
            11    9  12 1
            12   10  13 1
            13   10  14 2
            14   11  15 1
            15    9  11 2

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