KEGG   DRUG: D07448Help
Entry
D07448                      Drug                                   

Name
Amitriptyline (INN);
Laroxyl (TN)
Formula
C20H23N
Exact mass
277.1831
Mol weight
277.4033
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant, tricyclic
Remark
Same as: 
ATC code: 
Comment
Tricyclic antidepressants
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Antimigraines
Neurotransmitter transporter inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA09 Amitriptyline
      D07448  Amitriptyline (INN)
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Amitriptyline
    D07448  Amitriptyline (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K05035]
     Amitriptyline [ATC:N06AA09]
      D07448  Amitriptyline (INN)
    SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
     Amitriptyline [ATC:N06AA09]
      D07448  Amitriptyline (INN)
BRITE hierarchy
Other DBs
CAS: 
50-48-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C1x C    21.9800  -21.2100
            2   C8y C    21.1400  -20.0900
            3   C8y C    21.4200  -18.6900
            4   C2y C    22.6800  -18.1300
            5   C1x C    23.3800  -21.2100
            6   C8y C    23.9400  -18.7600
            7   C8y C    24.2900  -20.1600
            8   C8x C    20.4400  -17.7100
            9   C8x C    19.1100  -18.1300
            10  C8x C    18.7600  -19.4600
            11  C8x C    19.7400  -20.4400
            12  C8x C    25.6200  -20.5800
            13  C8x C    26.6700  -19.6000
            14  C8x C    26.3200  -18.2700
            15  C8x C    24.9900  -17.8500
            16  C2b C    22.6800  -16.7300
            17  C1b C    23.8700  -16.1000
            18  C1b C    25.0600  -16.8000
            19  N1c N    26.3200  -16.1000
            20  C1a C    27.5100  -16.8000
            21  C1a C    26.3200  -14.7000
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   19  21 1

» Japanese version   » Back

DBGET integrated database retrieval system