KEGG   DRUG: D07467Help
Entry
D07467                      Drug                                   

Name
Paromomycin (INN);
PRM;
Paromomycin (TN)
Formula
C23H45N5O14
Exact mass
615.2963
Mol weight
615.6285
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Streptomyces chrestomyceticus [TAX:68185]
Activity
Antidepressant;
Antibiotic, aminoglycoside [DS:H00360]
Remark
Same as: 
ATC code: 
Comment
Natural product
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA06 Paromomycin
      D07467  Paromomycin (INN)
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Paromomycin
    D07467  Paromomycin (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor [KO:K01977]
    Aminoglycosides
     Paromomycin [ATC:A07AA06]
      D07467  Paromomycin (INN)
BRITE hierarchy
Other DBs
CAS: 
7542-37-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        42
            1   C1y C    17.7100  -20.7900
            2   C1y C    17.7100  -22.1900
            3   C1y C    18.9000  -22.8900
            4   C1y C    20.0900  -22.1900
            5   C1y C    20.0900  -20.7900
            6   O2x O    18.9000  -20.0900
            7   O2a O    21.2800  -20.0900
            8   C1y C    23.5200  -18.9700
            9   C1y C    23.9400  -17.6400
            10  O2x O    22.8200  -16.8000
            11  C1y C    21.7000  -17.6400
            12  C1y C    22.1200  -18.9700
            13  O2a O    25.4800  -17.2200
            14  O1a O    25.8300  -20.0200
            15  C1y C    27.0200  -19.3200
            16  C1y C    28.2100  -19.9500
            17  C1x C    29.4000  -19.2500
            18  C1y C    29.4000  -17.8500
            19  C1y C    28.2100  -17.2200
            20  C1y C    27.0200  -17.9200
            21  N1a N    28.2100  -21.3500
            22  N1a N    30.5900  -17.1500
            23  O2a O    28.2100  -15.8200
            24  C1y C    29.4000  -15.1200
            25  O2x O    30.5900  -15.8200
            26  C1y C    31.8500  -15.1200
            27  C1y C    31.8500  -13.7200
            28  C1y C    30.5900  -13.0200
            29  C1y C    29.4000  -13.7200
            30  C1b C    32.9700  -15.7500
            31  O1a O    33.0400  -17.1500
            32  N1a N    28.2100  -13.0200
            33  O1a O    30.5900  -11.6200
            34  O1a O    32.9700  -13.0200
            35  C1b C    20.3700  -17.2200
            36  O1a O    24.2900  -20.0900
            37  O1a O    19.3200  -18.1300
            38  C1b C    16.5200  -20.0900
            39  O1a O    16.5200  -22.8900
            40  N1a N    21.2800  -22.8900
            41  O1a O    18.9000  -24.2200
            42  N1a N    15.2600  -20.7900
BOND        45
            1    19  23 1 #Down
            2    20  13 1 #Up
            3    10  11 1
            4    24  23 1 #Down
            5    11  12 1
            6    12   8 1
            7     5   6 1
            8     9  13 1 #Up
            9     6   1 1
            10   24  25 1
            11   25  26 1
            12   26  27 1
            13   27  28 1
            14   28  29 1
            15   29  24 1
            16   26  30 1 #Up
            17   15  14 1 #Down
            18   30  31 1
            19    5   7 1 #Down
            20   29  32 1 #Down
            21   28  33 1 #Up
            22    1   2 1
            23   27  34 1 #Down
            24    2   3 1
            25   11  35 1 #Up
            26   12   7 1 #Down
            27    3   4 1
            28    8  36 1 #Down
            29   15  16 1
            30   35  37 1
            31   16  17 1
            32    1  38 1 #Down
            33   17  18 1
            34    2  39 1 #Down
            35   18  19 1
            36    4  40 1 #Down
            37   19  20 1
            38    3  41 1 #Up
            39   20  15 1
            40   38  42 1
            41    4   5 1
            42   16  21 1 #Up
            43    8   9 1
            44   18  22 1 #Up
            45    9  10 1

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