KEGG   DRUG: D07483Help
Entry
D07483                      Drug                                   

Name
Azelastine (INN);
Optivar (TN)
Formula
C22H24ClN3O
Exact mass
381.1608
Mol weight
381.8985
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Antiasthmatic;
Antihistaminic
Remark
Same as: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC03 Azelastine
      D07483  Azelastine (INN)
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX19 Azelastine
      D07483  Azelastine (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX07 Azelastine
      D07483  Azelastine (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Azelastine
    D07483  Azelastine (INN)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Azelastine
    D07483  Azelastine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Azelastine
    D07483  Azelastine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Azelastine
      D07483  Azelastine (INN)
BRITE hierarchy
Other DBs
CAS: 
58581-89-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C8x C    12.8100  -29.7500
            2   C8x C    12.8100  -31.1500
            3   C8x C    14.0000  -31.8500
            4   C8y C    15.2600  -31.1500
            5   C8y C    15.2600  -29.7500
            6   C8x C    14.0000  -29.0500
            7   C8y C    16.4500  -31.8500
            8   N4y N    17.6400  -31.1500
            9   N5x N    17.6400  -29.7500
            10  C8y C    16.4500  -29.0500
            11  C1b C    16.4500  -27.6500
            12  C8y C    17.6400  -26.9500
            13  C8x C    18.8300  -27.6500
            14  C8x C    20.0900  -26.9500
            15  C8y C    20.0900  -25.5500
            16  C8x C    18.9000  -24.8500
            17  C8x C    17.6400  -25.5500
            18  X   Cl   21.2800  -24.8500
            19  C1y C    18.8300  -31.8500
            20  O5x O    16.4500  -33.2500
            21  C1x C    19.9500  -30.9400
            22  C1x C    21.2800  -31.2900
            23  N1y N    21.9100  -32.5500
            24  C1x C    18.8300  -33.2500
            25  C1x C    21.2800  -33.8100
            26  C1x C    19.9500  -34.0900
            27  C1a C    23.3100  -32.5500
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20   15  18 1
            21    8  19 1
            22    7  20 2
            23   22  23 1
            24   19  24 1
            25   23  25 1
            26   21  22 1
            27   24  26 1
            28   19  21 1
            29   25  26 1
            30   23  27 1

» Japanese version   » Back

DBGET integrated database retrieval system