KEGG   DRUG: D07519Help
Entry
D07519                      Drug                                   

Name
Benzylthiouracil;
Basdene (TN)
Formula
C11H10N2OS
Exact mass
218.0514
Mol weight
218.2749
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antithyroid
Remark
ATC code: 
Target
thyroid peroxidase inhibitor [HSA:7173] [KO:K00431];
deiodinase, iodothyronine, type I inhibitor [HSA:1733] [KO:K01562];
deiodinase, iodothyronine, type II inhibitor [HSA:1734] [KO:K17904]
  Pathway
hsa00350  Tyrosine metabolism
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05320  Autoimmune thyroid disease  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03B ANTITHYROID PREPARATIONS
    H03BA Thiouracils
     H03BA03 Benzylthiouracil
      D07519  Benzylthiouracil
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   thyroid peroxidase
    Benzylthiouracil
     D07519  Benzylthiouracil
   type I iodothyronine deiodinase
    Benzylthiouracil
     D07519  Benzylthiouracil
   type II iodothyronine deiodinase
    Benzylthiouracil
     D07519  Benzylthiouracil
BRITE hierarchy
Other DBs
CAS: 
33086-27-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   C5x C    28.0700  -17.3600
            2   C1z C    27.3700  -18.5500
            3   C2y C    28.0000  -19.8100
            4   N2x N    29.4000  -19.8100
            5   C2x C    30.1700  -18.6200
            6   N2x N    29.4700  -17.3600
            7   O5x O    27.3700  -16.1000
            8   C1b C    26.1800  -17.8500
            9   C1y C    24.9900  -18.5500
            10  C2x C    23.8000  -17.8500
            11  C2x C    22.5400  -18.5500
            12  C2x C    22.5400  -19.9500
            13  C2x C    23.8000  -20.6500
            14  C1x C    24.9900  -19.9500
            15  S2x S    26.6700  -19.8100
BOND        17
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 2
            8     8   2 1
            9     8   9 1
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15    9  14 1
            16   15   3 1
            17    2  15 1

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