KEGG   DRUG: BepridilHelp
Entry
D07520                      Drug                                   

Name
Bepridil (INN);
Bepadin (TN)
Formula
C24H34N2O
Exact mass
366.2671
Mol weight
366.5396
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01807  Phenylalkylamine derivative
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antiarrhythmic, Calcium antagonist, Coronary vasodilator
Comment
Class IV antiarrhythmic agent
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854];
KCNH2 [HSA:3757] [KO:K04905];
KCNQ1 [HSA:3784] [KO:K04926];
KCNA5 [HSA:3741] [KO:K04878];
KCND3 [HSA:3752] [KO:K04893];
KCNJ3 [HSA:3760] [KO:K04997];
KCNJ5 [HSA:3762] [KO:K04999];
KCNJ8 [HSA:3764] [KO:K05001];
KCNJ11 [HSA:3767] [KO:K05004];
KCNJ12 [HSA:3768] [KO:K05005];
sodium channel
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Calcium channel blocking drugs
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
    C08EA Phenylalkylamine derivatives
     C08EA02 Bepridil
      D07520  Bepridil (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    sodium channel
     Bepridil
      D07520  Bepridil (INN)
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Bepridil
      D07520  Bepridil (INN)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA5)
     Bepridil
      D07520  Bepridil (INN)
   K+ channel, KCND, Kv4.x (Shal)
    voltage-gated potassium channel (KCND3)
     Bepridil
      D07520  Bepridil (INN)
   K+ channel, KCNQ, Kv7.x (KQT-like)
    voltage-gated potassium channel (KCNQ1)
     Bepridil
      D07520  Bepridil (INN)
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH2)
     Bepridil
      D07520  Bepridil (INN)
  Related to voltage-gated cation channels
   Inward rectifier channel (Kir)
    potassium inwardly-rectifying channel (KCNJ3)
     Bepridil
      D07520  Bepridil (INN)
    potassium inwardly-rectifying channel (KCNJ5)
     Bepridil
      D07520  Bepridil (INN)
    potassium inwardly-rectifying channel (KCNJ11)
     Bepridil
      D07520  Bepridil (INN)
    potassium inwardly-rectifying channel (KCNJ12)
     Bepridil
      D07520  Bepridil (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Bepridil
    D07520  Bepridil (INN)
 CYP substrates
  CYP2C9
   Bepridil
    D07520  Bepridil (INN)
  CYP2D6
   Bepridil
    D07520  Bepridil (INN)
  CYP3A4
   Bepridil
    D07520  Bepridil (INN)
BRITE hierarchy
Other DBs
CAS: 
64706-54-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   N1c N    20.2300  -19.0400
            2   C1b C    21.4200  -19.7400
            3   C1b C    19.0400  -19.7400
            4   C1c C    22.6800  -19.0400
            5   C8y C    17.8500  -19.0400
            6   N1y N    23.8700  -19.7400
            7   C1b C    22.6800  -17.6400
            8   C8x C    16.5900  -19.7400
            9   C8x C    17.8500  -17.6400
            10  C1x C    24.9900  -18.9000
            11  C1x C    24.2900  -21.0700
            12  O2a O    23.8700  -16.9400
            13  C8x C    15.4000  -19.0400
            14  C8x C    16.5900  -16.9400
            15  C1x C    26.1800  -19.7400
            16  C1x C    25.6900  -21.0700
            17  C1b C    25.0600  -17.6400
            18  C8x C    15.4000  -17.6400
            19  C1c C    26.3200  -16.9400
            20  C1a C    27.5100  -17.6400
            21  C1a C    26.3200  -15.5400
            22  C8y C    20.2300  -17.6400
            23  C8x C    21.4200  -16.9400
            24  C8x C    21.4200  -15.5400
            25  C8x C    20.2300  -14.8400
            26  C8x C    19.0400  -15.5400
            27  C8x C    19.0400  -16.9400
BOND        29
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 2
            14   10  15 1
            15   11  16 1
            16   12  17 1
            17   13  18 2
            18   17  19 1
            19   19  20 1
            20   19  21 1
            21   14  18 1
            22   15  16 1
            23    1  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1

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