KEGG   DRUG: D07520Help
Entry
D07520                      Drug                                   

Name
Bepridil (INN);
Bepadin (TN)
Formula
C24H34N2O
Exact mass
366.2671
Mol weight
366.5396
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic;
Calcium antagonist;
Coronary vasodilator
Remark
Same as: 
ATC code: 
Comment
Class IV antiarrhythmic agent
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854];
voltage-gated potassium channel (KCNH2) blocker [HSA:3757] [KO:K04905];
voltage-gated potassium channel (KCNQ1) blocker [HSA:3784] [KO:K04926];
voltage-gated potassium channel (KCNA5) blocker [HSA:3741] [KO:K04878];
voltage-gated potassium channel (KCND3) blocker [HSA:3752] [KO:K04893];
potassium inwardly-rectifying channel (KCNJ3) [HSA:3760] [KO:K04997];
potassium inwardly-rectifying channel (KCNJ5) [HSA:3762] [KO:K04999];
potassium inwardly-rectifying channel (KCNJ8) [HSA:3764] [KO:K05001];
potassium inwardly-rectifying channel (KCNJ11) [HSA:3767] [KO:K05004];
potassium inwardly-rectifying channel (KCNJ12) [HSA:3768] [KO:K05005];
sodium channel blocker
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Calcium channel blocking drugs
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
    C08EA Phenylalkylamine derivatives
     C08EA02 Bepridil
      D07520  Bepridil (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    sodium channel
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA5) [HSA:3741] [KO:K04878]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
   K+ channel, KCND, Kv4.x (Shal)
    voltage-gated potassium channel (KCND3) [HSA:3752] [KO:K04893]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
   K+ channel, KCNQ, Kv7.x (KQT-like)
    voltage-gated potassium channel (KCNQ1) [HSA:3784] [KO:K04926]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH2) [HSA:3757] [KO:K04905]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
  Related to voltage-gated cation channels
   Inward rectifier channel (Kir)
    potassium inwardly-rectifying channel (KCNJ3) [HSA:3760] [KO:K04997]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
    potassium inwardly-rectifying channel (KCNJ5) [HSA:3762] [KO:K04999]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
    potassium inwardly-rectifying channel (KCNJ11) [HSA:3767] [KO:K05004]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
    potassium inwardly-rectifying channel (KCNJ12) [HSA:3768] [KO:K05005]
     Bepridil [ATC:C08EA02]
      D07520  Bepridil (INN)
BRITE hierarchy
Other DBs
CAS: 
64706-54-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   N1c N    20.2300  -19.0400
            2   C1b C    21.4200  -19.7400
            3   C1b C    19.0400  -19.7400
            4   C1c C    22.6800  -19.0400
            5   C8y C    17.8500  -19.0400
            6   N1y N    23.8700  -19.7400
            7   C1b C    22.6800  -17.6400
            8   C8x C    16.5900  -19.7400
            9   C8x C    17.8500  -17.6400
            10  C1x C    24.9900  -18.9000
            11  C1x C    24.2900  -21.0700
            12  O2a O    23.8700  -16.9400
            13  C8x C    15.4000  -19.0400
            14  C8x C    16.5900  -16.9400
            15  C1x C    26.1800  -19.7400
            16  C1x C    25.6900  -21.0700
            17  C1b C    25.0600  -17.6400
            18  C8x C    15.4000  -17.6400
            19  C1c C    26.3200  -16.9400
            20  C1a C    27.5100  -17.6400
            21  C1a C    26.3200  -15.5400
            22  C8y C    20.2300  -17.6400
            23  C8x C    21.4200  -16.9400
            24  C8x C    21.4200  -15.5400
            25  C8x C    20.2300  -14.8400
            26  C8x C    19.0400  -15.5400
            27  C8x C    19.0400  -16.9400
BOND        29
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 2
            14   10  15 1
            15   11  16 1
            16   12  17 1
            17   13  18 2
            18   17  19 1
            19   19  20 1
            20   19  21 1
            21   14  18 1
            22   15  16 1
            23    1  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1

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