KEGG   DRUG: D07537Help
Entry
D07537                      Drug                                   

Name
Bopindolol (INN);
Sandonorm (TN)
Formula
C23H28N2O3
Exact mass
380.21
Mol weight
380.48
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive;
beta-Adrenergic blocking
Remark
ATC code: 
Drug group: 
Comment
Prodrug, active substance: Propranolol [DR:D08443]
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA17 Bopindolol
      D07537  Bopindolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Bopindolol
      D07537  Bopindolol (INN)
    beta2-adrenergic receptor
     Bopindolol
      D07537  Bopindolol (INN)
    beta3-adrenergic receptor
     Bopindolol
      D07537  Bopindolol (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Bopindolol
    D07537  Bopindolol (INN)
BRITE hierarchy
Other DBs
CAS: 
62658-63-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   O2a O    22.8900  -16.9400
            2   C8y C    22.8900  -18.2700
            3   C8x C    24.1500  -18.9700
            4   C8x C    24.1500  -20.3700
            5   C8x C    22.8900  -21.0700
            6   C8y C    21.7000  -18.9700
            7   C8y C    21.7000  -20.3700
            8   N4x N    20.3700  -20.7900
            9   C8y C    19.5300  -19.6000
            10  C8x C    20.3700  -18.4800
            11  C1a C    18.1300  -19.6000
            12  C1b C    24.1500  -16.2400
            13  C1c C    25.3400  -16.9400
            14  C1b C    26.5300  -16.2400
            15  N1b N    27.7200  -16.9400
            16  C1d C    28.9100  -16.2400
            17  C1a C    30.1700  -16.9400
            18  C1a C    28.9100  -14.8400
            19  C1a C    30.1700  -15.4700
            20  C7a C    26.0400  -19.6000
            21  O6a O    25.3400  -20.7900
            22  C8y C    27.4400  -19.6000
            23  C8x C    28.1400  -20.7900
            24  C8x C    29.5400  -20.7900
            25  C8x C    28.1400  -18.3400
            26  C8x C    29.5400  -18.3400
            27  C8x C    30.2400  -19.6000
            28  O7a O    25.3400  -18.3400
BOND        30
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   7 1
            5     6   2 1
            6     1   2 1
            7     6   7 2
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11   10   6 1
            12    9  11 1
            13    1  12 1
            14   12  13 1
            15   16  17 1
            16   16  18 1
            17   16  19 1
            18   13  14 1
            19   14  15 1
            20   15  16 1
            21   20  21 2
            22   20  22 1
            23   22  23 1
            24   23  24 2
            25   22  25 2
            26   25  26 1
            27   26  27 2
            28   27  24 1
            29   20  28 1
            30   13  28 1

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