KEGG   DRUG: D07593Help
Entry
D07593                      Drug                                   

Name
Buspirone (INN);
Gen-Buspirone (TN)
Formula
C21H31N5O2
Exact mass
385.2478
Mol weight
385.5031
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer
Remark
Same as: 
ATC code: 
Drug group: 
Target
5-HT1A-receptor agonist [HSA:3350] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
Anxiolytics
Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BE Azaspirodecanedione derivatives
     N05BE01 Buspirone
      D07593  Buspirone (INN)
USP drug classification [BR:br08302]
 Anxiolytics
  Anxiolytics, Other
   Buspirone
    D07593  Buspirone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1A-receptor
     Buspirone
      D07593  Buspirone (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A
   Buspirone
    D07593  Buspirone (INN)
BRITE hierarchy
Other DBs
CAS: 
36505-84-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1z C    30.3800  -15.6800
            2   C1x C    29.1900  -14.9800
            3   C1x C    30.3800  -17.0800
            4   C5x C    28.0000  -15.6800
            5   C5x C    29.1900  -17.7800
            6   N1y N    28.0000  -17.0800
            7   O5x O    26.7400  -14.9800
            8   O5x O    29.1900  -19.1100
            9   C1b C    26.8100  -17.7800
            10  C1b C    25.5500  -17.0800
            11  C1b C    24.3600  -17.7800
            12  C1b C    23.1700  -17.0800
            13  N1y N    21.9800  -17.8500
            14  C1x C    20.7200  -17.1500
            15  C1x C    21.9800  -19.2500
            16  C1x C    19.5300  -17.8500
            17  C1x C    20.7200  -19.8800
            18  N1y N    19.5300  -19.1800
            19  C8y C    18.3400  -19.8800
            20  N5x N    17.1500  -19.1800
            21  N5x N    18.2700  -21.2800
            22  C8x C    15.8200  -19.8800
            23  C8x C    17.0800  -21.9800
            24  C8x C    15.8200  -21.2800
            25  C1x C    31.7100  -16.1000
            26  C1x C    32.5500  -14.9800
            27  C1x C    31.7100  -13.8600
            28  C1x C    30.3800  -14.2800
BOND        31
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 2
            7     5   8 2
            8     6   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   19  20 1
            20   19  21 2
            21   20  22 2
            22   21  23 1
            23   22  24 1
            24    5   6 1
            25   17  18 1
            26   23  24 2
            27    1  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31    1  28 1

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