KEGG   DRUG: D07607Help
Entry
D07607                      Drug                                   

Name
Capreomycin (INN);
CPRM
Formula
C19H30N12O6(R1)(R2)
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Saccharothrix mutabilis subsp. capreolus [TAX:66854]
Activity
Antibiotic;
polypeptide [DS:H00342]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Mixture of Capreomycin IA and IB
Capreomycin IA (CAS 37280-35-6) (R1 = -OH, R2 = -COCH2CH(NH2)(CH2)3NH2)
Capreomycin IB (CAS 33490-33-4) (R 1= -H, R2 = -COCH2CH(NH2)(CH2)3NH2)
Capreomycin IIA (CAS 62639-89-8) (R1 = -OH, R2 = -H)
Capreomycin IIB (CAS 62639-90-1) (R1 = -H, R2 = -H)
Natural product
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980];
16S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AB Antibiotics
     J04AB30 Capreomycin
      D07607  Capreomycin (INN)
USP drug classification [BR:br08302]
 Antimycobacterials
  Antituberculars
   Capreomycin
    D07607  Capreomycin (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Others
    Peptides
     Capreomycin
      D07607  Capreomycin (INN)
BRITE hierarchy
Other DBs
CAS: 
11003-38-6
PubChem: 
NIKKAJI: 
KCF data Show

ATOM        39
            1   C1y C    16.5327  -13.3355
            2   N1x N    17.7198  -12.6372
            3   C5x C    18.9767  -13.3355
            4   C1y C    20.1638  -12.6372
            5   N1x N    21.3508  -13.3355
            6   C5x C    22.5379  -12.6372
            7   C1y C    23.7250  -13.3355
            8   N1a N    24.9120  -12.6372
            9   C1b C    15.3457  -12.6372
            10  Z   R#   12.4129  -12.6372
            11  N1b N    14.1586  -13.3355
            12  C5x C    16.5327  -14.6622
            13  N1x N    17.7198  -15.3605
            14  C2y C    17.7198  -16.7571
            15  O5x O    15.3457  -15.3605
            16  O5x O    18.9767  -14.6622
            17  C1b C    20.1638  -11.2407
            18  O5x O    22.5379  -11.2407
            19  Z   R#   18.8369  -10.4024
            20  C1x C    23.7250  -14.6622
            21  N1x N    22.5379  -15.3605
            22  C5x C    22.5379  -16.7571
            23  C1y C    21.3508  -17.4553
            24  O5x O    23.7250  -17.4553
            25  N1x N    20.1638  -16.7571
            26  C5x C    18.9767  -17.4553
            27  O5x O    18.9765  -18.8519
            28  C1y C    21.3508  -19.1312
            29  N1x N    20.1638  -19.7596
            30  C1y C    20.1638  -21.1562
            31  N2x N    21.3508  -21.8545
            32  C2x C    22.5379  -21.1562
            33  C1x C    22.5379  -19.7596
            34  N1a N    18.9767  -21.8545
            35  C2b C    16.5327  -17.4553
            36  N1b N    15.3457  -16.7571
            37  C5a C    14.1586  -17.5252
            38  N1a N    12.9715  -16.8269
            39  O5a O    14.1586  -18.9217
BOND        40
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1 #Up
            8    10  11 1
            9     9  11 1
            10    1   9 1 #Up
            11    1  12 1
            12   12  13 1
            13   13  14 1
            14   12  15 2
            15    3  16 2
            16    4  17 1 #Up
            17    6  18 2
            18   17  19 1
            19    7  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 1
            25   25  26 1
            26   26  14 1
            27   26  27 2
            28   23  28 1
            29   28  29 1
            30   29  30 1
            31   30  31 1
            32   31  32 2
            33   32  33 1
            34   28  33 1
            35   30  34 1
            36   14  35 2
            37   35  36 1
            38   36  37 1
            39   37  38 1
            40   37  39 2

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