KEGG   DRUG: CevimelineHelp
Entry
D07667                      Drug                                   

Name
Cevimeline (INN)
Formula
C10H17NOS
Exact mass
199.1031
Mol weight
199.3131
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Other
 DG01719  Parasympathomimetic agent
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
ATC code: 
Chemical group: 
Activity
Salivation accelaletor, Muscarinic receptor M3 agonist
Comment
Arecoline derivative
Target
CHRM1 [HSA:1128] [KO:K04129];
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX03 Cevimeline
      D07667  Cevimeline (INN)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Cevimeline
   D07667  Cevimeline (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M1
     Cevimeline
      D07667  Cevimeline (INN)
    muscarinic cholinergic receptor M3
     Cevimeline
      D07667  Cevimeline (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Cevimeline
    D07667  Cevimeline (INN)
  CYP3A4
   Cevimeline
    D07667  Cevimeline (INN)
BRITE hierarchy
Other DBs
CAS: 
107233-08-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        13
            1   C1z C    24.2900  -17.4300
            2   C1y C    24.2900  -16.0300
            3   C1x C    23.0300  -18.2000
            4   C1x C    23.0300  -15.2600
            5   C1x C    23.4500  -16.8700
            6   N1y N    21.7700  -17.4300
            7   C1x C    21.7700  -16.0300
            8   C1x C    22.7500  -16.3800
            9   O2x O    24.2900  -18.8300
            10  C1y C    25.6900  -19.3200
            11  S2x S    26.5300  -18.1300
            12  C1x C    25.6900  -16.9400
            13  C1a C    26.1100  -20.6500
BOND        15
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   7 1
            9     6   8 1
            10    1   9 1 #Up
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14    1  12 1
            15   10  13 1 #Down

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