KEGG   DRUG: D07667Help
Entry
D07667                      Drug                                   

Name
Cevimeline (INN)
Formula
C10H17NOS
Exact mass
199.1031
Mol weight
199.3131
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Nootropic
Remark
ATC code: 
Target
muscarinic cholinergic receptor M1, M3 agonist [HSA:1128 1131] [KO:K04129 K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX03 Cevimeline
      D07667  Cevimeline (INN)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Cevimeline
   D07667  Cevimeline (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M1 [HSA:1128] [KO:K04129]
     Cevimeline [ATC:N07AX03]
      D07667  Cevimeline (INN)
    muscarinic cholinergic receptor M3 [HSA:1131] [KO:K04131]
     Cevimeline [ATC:N07AX03]
      D07667  Cevimeline (INN)
BRITE hierarchy
Other DBs
CAS: 
107233-08-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        13
            1   C1z C    24.2900  -17.4300
            2   C1y C    24.2900  -16.0300
            3   C1x C    23.0300  -18.2000
            4   C1x C    23.0300  -15.2600
            5   C1x C    23.4500  -16.8700
            6   N1y N    21.7700  -17.4300
            7   C1x C    21.7700  -16.0300
            8   C1x C    22.7500  -16.3800
            9   O2x O    24.2900  -18.8300
            10  C1y C    25.6900  -19.3200
            11  S2x S    26.5300  -18.1300
            12  C1x C    25.6900  -16.9400
            13  C1a C    26.1100  -20.6500
BOND        15
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   7 1
            9     6   8 1
            10    1   9 1 #Up
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14    1  12 1
            15   10  13 1 #Down

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