KEGG   DRUG: D07674Help
Entry
D07674                      Drug                                   

Name
Chloramphenicol stearate;
Quemicetina (TN)
Formula
C29H46Cl2N2O6
Exact mass
588.2733
Mol weight
589.5913
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, chloramphenicol
Remark
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D07674  Chloramphenicol stearate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D07674  Chloramphenicol stearate
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D07674  Chloramphenicol stearate
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D07674  Chloramphenicol stearate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D07674  Chloramphenicol stearate
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D07674  Chloramphenicol stearate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D07674  Chloramphenicol stearate
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Chloramphenicol
    D07674  Chloramphenicol stearate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Amphenicols
     Chloramphenicol
      D07674  Chloramphenicol stearate
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Chloramphenicol
    D07674  Chloramphenicol stearate
 Inhbitors
  CYP2C19
   Chloramphenicol
    D07674  Chloramphenicol stearate
  CYP3A4
   Chloramphenicol
    D07674  Chloramphenicol stearate
  CYP3A5
   Chloramphenicol
    D07674  Chloramphenicol stearate
  CYP3A7
   Chloramphenicol
    D07674  Chloramphenicol stearate
BRITE hierarchy
Other DBs
CAS: 
16255-48-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        39
            1   C8y C     8.9879  -15.5006
            2   C1c C     8.9879  -16.9031
            3   C8x C     7.7958  -14.7994
            4   C8x C    10.2501  -14.7994
            5   C1c C    10.2501  -17.6043
            6   O1a O     7.7958  -17.6043
            7   C8x C     7.7958  -13.3268
            8   C8x C    10.2501  -13.3268
            9   N1b N    11.4422  -16.9031
            10  C1b C    10.2500  -19.0068
            11  C8y C     8.9879  -12.6255
            12  C5a C    12.6343  -17.6043
            13  O7a O     9.0579  -19.7081
            14  N2b N     8.9879  -11.2231 #+
            15  C1c C    13.8966  -16.9031
            16  O5a O    12.6343  -19.0068
            17  O3a O     7.7958  -10.5218
            18  O3a O    10.2501  -10.5218 #-
            19  X   Cl   15.0887  -17.6043
            20  X   Cl   13.8966  -15.5006
            21  C7a C     9.0579  -21.1105
            22  O6a O     7.8658  -21.8118
            23  C1b C    10.2500  -21.8118
            24  C1b C    11.5122  -21.1105
            25  C1b C    12.7043  -21.8118
            26  C1b C    13.8964  -21.1105
            27  C1b C    15.0885  -21.8118
            28  C1b C    16.3508  -21.1105
            29  C1b C    17.5429  -21.8118
            30  C1b C    18.7350  -21.1105
            31  C1b C    19.9271  -21.8118
            32  C1b C    21.1192  -21.1105
            33  C1b C    22.3814  -21.8118
            34  C1b C    23.5735  -21.1807
            35  C1b C    24.7657  -21.8118
            36  C1b C    25.9578  -21.1807
            37  C1b C    27.1499  -21.8118
            38  C1b C    28.3379  -21.0665
            39  C1a C    29.5696  -21.7184
BOND        39
            1    15  19 1
            2    15  20 1
            3     8  11 1
            4    13  21 1
            5     1   2 1
            6    21  22 2
            7     1   3 2
            8    21  23 1
            9     1   4 1
            10   23  24 1
            11    2   5 1
            12   24  25 1
            13    2   6 1 #Down
            14   25  26 1
            15    3   7 1
            16   26  27 1
            17    4   8 2
            18   27  28 1
            19    5   9 1
            20   28  29 1
            21    5  10 1
            22   29  30 1
            23    7  11 2
            24   30  31 1
            25    9  12 1
            26   31  32 1
            27   10  13 1
            28   32  33 1
            29   11  14 1
            30   33  34 1
            31   12  15 1
            32   34  35 1
            33   12  16 2
            34   35  36 1
            35   14  17 2
            36   36  37 1
            37   14  18 1
            38   37  38 1
            39   38  39 1

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