KEGG   DRUG: D07675Help
Entry
D07675                      Drug                                   

Name
Chloramphenicol succinate;
Chloramphenicol ICN (TN)
Formula
C15H16Cl2N2O8
Exact mass
422.0284
Mol weight
423.2021
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, chloramphenicol
Remark
Comment
prodrug, active substance: Chloramphenicol [DR:D00104]
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D07675  Chloramphenicol succinate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D07675  Chloramphenicol succinate
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D07675  Chloramphenicol succinate
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D07675  Chloramphenicol succinate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D07675  Chloramphenicol succinate
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D07675  Chloramphenicol succinate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D07675  Chloramphenicol succinate
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Chloramphenicol
    D07675  Chloramphenicol succinate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Amphenicols
     Chloramphenicol
      D07675  Chloramphenicol succinate
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Chloramphenicol
    D07675  Chloramphenicol succinate
 Inhbitors
  CYP2C19
   Chloramphenicol
    D07675  Chloramphenicol succinate
  CYP3A4
   Chloramphenicol
    D07675  Chloramphenicol succinate
  CYP3A5
   Chloramphenicol
    D07675  Chloramphenicol succinate
  CYP3A7
   Chloramphenicol
    D07675  Chloramphenicol succinate
BRITE hierarchy
Other DBs
CAS: 
3544-94-3
PubChem: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C8y C    21.4900  -15.5400
            2   C1c C    21.4900  -16.9400
            3   C8x C    20.3000  -14.7700
            4   C8x C    22.7500  -14.7700
            5   C1c C    22.7500  -17.5700
            6   O1a O    20.3000  -17.5700
            7   C8x C    20.3000  -13.3700
            8   C8x C    22.7500  -13.3700
            9   N1b N    23.9400  -16.9400
            10  C8y C    21.4900  -12.7400
            11  C5a C    25.1300  -17.6400
            12  N2b N    21.4900  -11.3400 #+
            13  C1c C    26.3200  -16.9400
            14  O5a O    25.1300  -18.9700
            15  O3a O    20.3000  -10.6400
            16  O3a O    22.6800  -10.6400 #-
            17  X   Cl   27.5100  -17.6400
            18  X   Cl   26.3200  -15.5400
            19  C1b C    22.7500  -19.0400
            20  O7a O    21.4900  -19.7400
            21  C7a C    21.4900  -21.1400
            22  O6a O    20.3000  -21.8400
            23  C1b C    22.7500  -21.8400
            24  C1b C    24.0100  -21.1400
            25  C6a C    25.2000  -21.8400
            26  O6a O    26.3900  -21.1400
            27  O6a O    25.2000  -23.3100
BOND        27
            1     5   9 1
            2     7  10 2
            3     9  11 1
            4    10  12 1
            5    11  13 1
            6    11  14 2
            7    12  15 2
            8    12  16 1
            9    13  17 1
            10   13  18 1
            11    8  10 1
            12    1   2 1
            13    1   3 2
            14    1   4 1
            15    2   5 1
            16    2   6 1 #Down
            17    3   7 1
            18    4   8 2
            19    5  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 2
            23   21  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   25  27 2

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