KEGG   DRUG: D07699Help
Entry
D07699                      Drug                                   

Name
Cilazapril (INN);
Inhibace (TN)
Formula
C22H31N3O5
Exact mass
417.2264
Mol weight
417.4986
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
ACE-inhibitor, Antihypertensive
Remark
ATC code: 
Drug group: 
Comment
prodrug, active substance: Cilazaprilat [CPD:C17309]
Target
angiotensin-converting enzyme (ACE) inhibitor [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system  
 
Interaction
Drug interaction
Structure map
Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA08 Cilazapril
      D07699  Cilazapril (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   angiotensin-converting enzyme (ACE)
    Cilazapril
     D07699  Cilazapril (INN)
BRITE hierarchy
Other DBs
CAS: 
88768-40-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C1x C    19.3200  -20.7900
            2   N1y N    18.4800  -19.6700
            3   N1y N    18.8300  -18.3400
            4   C5x C    20.0900  -17.7800
            5   C1x C    20.7200  -20.7900
            6   C1y C    21.3500  -18.4100
            7   C1x C    21.6300  -19.7400
            8   C1y C    17.7800  -17.3600
            9   C1x C    16.4500  -17.7800
            10  C1x C    16.1000  -19.1100
            11  C1x C    17.1500  -20.0900
            12  C6a C    18.1300  -16.0300
            13  O6a O    19.3900  -15.6100
            14  O6a O    17.0100  -15.0500
            15  O5x O    20.1600  -16.3800
            16  C7a C    24.0800  -19.7400
            17  C1c C    24.0800  -18.3400
            18  N1b N    22.8200  -17.6400
            19  C1b C    25.2700  -17.6400
            20  C1b C    26.4600  -18.3400
            21  C8y C    27.6500  -17.6400
            22  O7a O    25.2700  -20.4400
            23  O6a O    22.8900  -20.4400
            24  C1b C    26.4600  -19.7400
            25  C1a C    27.6500  -20.4400
            26  C8x C    28.8400  -18.3400
            27  C8x C    30.0300  -17.6400
            28  C8x C    30.0300  -16.2400
            29  C8x C    28.8400  -15.5400
            30  C8x C    27.6500  -16.2400
BOND        32
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    2  11 1
            13    8  12 1 #Up
            14   12  13 2
            15   12  14 1
            16    4  15 2
            17   17  16 1 #Up
            18   17  18 1
            19    6  18 1 #Up
            20   17  19 1
            21   19  20 1
            22   20  21 1
            23   16  22 1
            24   16  23 2
            25   22  24 1
            26   24  25 1
            27   21  26 2
            28   26  27 1
            29   27  28 2
            30   28  29 1
            31   29  30 2
            32   21  30 1

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