KEGG   DRUG: Ciprofloxacin lactateHelp
Entry
D07702                      Drug                                   

Name
Ciprofloxacin lactate;
Ciproxin (TN)
Formula
C17H18FN3O3. C3H6O3
Exact mass
421.1649
Mol weight
421.4195
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Cyp substrate
 DG01892  CYP1A2 substrate
Cyp inhibitor
 DG01634  CYP1A2 inhibitor
 DG01522  CYP3A4 inhibitor
 DG01915  CYP3A5 ihibitor
Remark
ATC code: 
Chemical group: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376]
Interaction
CYP inhibition: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA02 Ciprofloxacin
      D07702  Ciprofloxacin lactate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE03 Ciprofloxacin
      D07702  Ciprofloxacin lactate
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA15 Ciprofloxacin
      D07702  Ciprofloxacin lactate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA07 Ciprofloxacin
      D07702  Ciprofloxacin lactate
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Ciprofloxacin
      D07702  Ciprofloxacin lactate
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
  CYP3A4
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
  CYP3A5
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
  CYP3A7
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
  CYP3A
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
 CYP substrates
  CYP1A2
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
  CYP3A4
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
 Transporter substrates
  OAT1
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
  OAT3
   Ciprofloxacin
    D07702  Ciprofloxacin lactate
BRITE hierarchy
Other DBs
CAS: 
97867-33-9
PubChem: 
LigandBox: 
KCF data Show

ATOM        30
            1   C8y C    21.8133  -17.0568
            2   C8y C    21.8133  -18.4608
            3   C8x C    23.0066  -19.1627
            4   C8y C    24.2702  -18.4608
            5   C8y C    24.2702  -17.0568
            6   C8x C    23.0066  -16.3549
            7   N4y N    25.4635  -19.1627
            8   C8x C    26.6569  -18.4608
            9   C8y C    26.6569  -17.0568
            10  C8y C    25.4635  -16.3549
            11  N1y N    20.6199  -19.1627
            12  C1x C    19.4266  -18.4608
            13  C1x C    18.1631  -19.1627
            14  N1x N    18.1631  -20.5667
            15  C1x C    19.3564  -21.2686
            16  C1x C    20.6199  -20.5667
            17  X   F    20.6199  -16.3549
            18  O5x O    25.4635  -14.9509
            19  C6a C    27.8502  -16.3549
            20  O6a O    29.0435  -17.0568
            21  O6a O    27.8502  -14.9509
            22  C1y C    25.4635  -20.5667
            23  C1x C    26.1655  -21.7600
            24  C1x C    24.7615  -21.7600
            25  C6a C    34.0900  -18.3400
            26  O6a O    35.3024  -19.0400
            27  C1c C    32.8776  -19.0400
            28  O6a O    34.0900  -16.9400
            29  O1a O    31.6821  -18.3496
            30  C1a C    32.8775  -20.4398
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    2  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   11  16 1
            19    1  17 1
            20   10  18 2
            21    9  19 1
            22   19  20 1
            23   19  21 2
            24    7  22 1
            25   22  23 1
            26   22  24 1
            27   23  24 1
            28   25  26 1
            29   25  27 1
            30   25  28 2
            31   27  29 1
            32   27  30 1

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