KEGG   DRUG: D07710Help
Entry
D07710                      Drug                                   

Name
Clarithromycin lactobionate;
Klacid (TN)
Formula
C38H69NO13. C12H22O12
Exact mass
1105.588
Mol weight
1106.2492
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, macrolide
Remark
ATC code: 
Comment
Macrolide antibiotic
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA09 Clarithromycin
      D07710  Clarithromycin lactobionate
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Clarithromycin
    D07710  Clarithromycin lactobionate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Macrolides
     Clarithromycin [ATC:J01FA09]
      D07710  Clarithromycin lactobionate
BRITE hierarchy
Other DBs
CAS: 
135326-55-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        76
            1   C1y C    13.5631   -8.5875
            2   C1z C    13.5631   -7.2650
            3   C1y C    12.3798   -9.2836
            4   O2a O    15.0944   -9.9100
            5   C1x C    12.3798   -6.5690
            6   C1y C    12.3798  -10.6757
            7   C1a C    11.1957   -8.5191
            8   C1y C    16.8345   -9.0748
            9   C1y C    12.3798   -5.1769
            10  O2a O    13.1454  -11.9982
            11  C1y C    11.1965  -11.3021
            12  C1y C    17.9482   -9.8404
            13  O2x O    16.8345   -7.7523
            14  C5x C    11.1965   -4.5505
            15  C1a C    13.5631   -4.5505
            16  C1y C    14.1895  -13.1118
            17  C7x C    10.0132  -10.6757
            18  C1a C    11.1965  -12.6942
            19  C1y C    19.2011   -9.2140
            20  O1a O    17.9482  -11.1629
            21  C1y C    18.0874   -7.1258
            22  C1y C    10.0132   -5.1769
            23  O5x O    11.1965   -3.1584
            24  C1x C    14.1895  -14.5039
            25  O2x O    15.3728  -12.4158
            26  O7x O    10.0132   -9.2836
            27  O6a O     8.9691  -11.5805
            28  C1x C    19.2011   -7.8219
            29  C1a C    18.1570   -5.7337
            30  C1y C    10.0132   -6.5690
            31  C1a C     8.8995   -4.5505
            32  C1z C    15.3728  -15.1304
            33  C1y C    16.4865  -13.1118
            34  C1y C     8.8995   -8.5875
            35  C1z C     8.8995   -7.2650
            36  O1a O    11.1965   -7.2650
            37  C1y C    16.4865  -14.5039
            38  O2a O    15.3728  -16.4529
            39  C1a C    17.6698  -12.4158
            40  C1b C     7.7163   -9.2836
            41  C1a C     7.6467   -7.8219
            42  O1a O     7.6467   -6.5690
            43  O1a O    17.6698  -15.1304
            44  C1a C     7.7163  -10.3973
            45  C1a C    14.7463   -7.9611
            46  C1a C    16.5561  -17.1489
            47  C1a C    14.1199  -15.8264
            48  O2a O    14.2591   -6.0818
            49  C1a C    15.6512   -6.0818
            50  N1c N    20.3843   -9.9100
            51  C1a C    21.6372   -9.2836
            52  C1a C    20.3843  -11.3717
            53  C1c C    32.2700   -9.5900
            54  C1c C    33.4600   -8.9600
            55  C1c C    31.0800   -8.8900
            56  C1b C    29.8200   -9.5900
            57  O1a O    28.6300   -8.8900
            58  O1a O    31.0800   -7.4900
            59  C1c C    34.6500   -9.5900
            60  C6a C    35.9100   -8.8900
            61  O6a O    37.1000   -9.5900
            62  O6a O    35.9100   -7.4900
            63  C1y C    31.0800  -11.7600
            64  O2x O    29.8900  -11.0600
            65  C1y C    31.0800  -13.0900
            66  C1y C    28.7000  -11.7600
            67  C1y C    29.8900  -13.7900
            68  O1a O    32.3400  -13.7900
            69  C1y C    28.7000  -13.0900
            70  C1b C    27.4400  -11.0600
            71  O1a O    29.8900  -15.1900
            72  O1a O    27.4400  -13.7900
            73  O1a O    26.2500  -11.7600
            74  O2a O    32.2700  -11.0600
            75  O1a O    33.4600   -7.4900
            76  O1a O    34.6500  -11.0600
BOND        78
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     3   6 1
            6     3   7 1 #Down
            7     8   4 1 #Down
            8     5   9 1
            9     6  10 1 #Down
            10    6  11 1
            11    8  12 1
            12    8  13 1
            13    9  14 1
            14    9  15 1 #Down
            15   16  10 1 #Down
            16   11  17 1
            17   11  18 1 #Up
            18   12  19 1
            19   12  20 1 #Up
            20   13  21 1
            21   14  22 1
            22   14  23 2
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   21  29 1 #Down
            29   22  30 1
            30   22  31 1 #Up
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   30  35 1
            35   30  36 1 #Up
            36   32  37 1
            37   32  38 1 #Down
            38   33  39 1 #Up
            39   34  40 1 #Down
            40   35  41 1 #Down
            41   35  42 1 #Up
            42   37  43 1 #Down
            43   40  44 1
            44   21  28 1
            45   33  37 1
            46   34  35 1
            47    2  45 1 #Down
            48   38  46 1
            49   32  47 1
            50    2  48 1 #Up
            51   48  49 1
            52   19  50 1 #Down
            53   50  51 1
            54   50  52 1
            55   53  54 1
            56   53  55 1
            57   55  56 1
            58   56  57 1
            59   55  58 1 #Up
            60   54  59 1
            61   59  60 1
            62   60  61 1
            63   60  62 2
            64   63  64 1
            65   63  65 1
            66   64  66 1
            67   65  67 1
            68   65  68 1 #Down
            69   66  69 1
            70   66  70 1 #Up
            71   67  71 1 #Up
            72   69  72 1 #Up
            73   70  73 1
            74   67  69 1
            75   63  74 1 #Up
            76   53  74 1 #Down
            77   54  75 1 #Down
            78   59  76 1 #Down

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