KEGG   DRUG: D07710Help
Entry
D07710                      Drug                                   

Name
Clarithromycin lactobionate;
Klacid (TN)
Formula
C38H69NO13. C12H22O12
Exact mass
1105.588
Mol weight
1106.2492
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, macrolide
Remark
ATC code: 
Drug group: 
Comment
Macrolide antibiotic
Target
50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
Ribosome
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA09 Clarithromycin
      D07710  Clarithromycin lactobionate
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Clarithromycin
    D07710  Clarithromycin lactobionate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   50S subunit inhibitor
    Macrolides
     Clarithromycin
      D07710  Clarithromycin lactobionate
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C8
   Clarithromycin
    D07710  Clarithromycin lactobionate
  CYP2C19
   Clarithromycin
    D07710  Clarithromycin lactobionate
  CYP3A
   Clarithromycin
    D07710  Clarithromycin lactobionate
 CYP substrates
  CYP3A4
   Clarithromycin
    D07710  Clarithromycin lactobionate
 Transporter inhibitors
  ABCB1
   Clarithromycin
    D07710  Clarithromycin lactobionate
  SLCO1B1
   Clarithromycin
    D07710  Clarithromycin lactobionate
  SLCO1B3
   Clarithromycin
    D07710  Clarithromycin lactobionate
BRITE hierarchy
Other DBs
CAS: 
135326-55-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        76
            1   C1y C    13.5631   -8.5875
            2   C1z C    13.5631   -7.2650
            3   C1y C    12.3798   -9.2836
            4   O2a O    15.0944   -9.9100
            5   C1x C    12.3798   -6.5690
            6   C1y C    12.3798  -10.6757
            7   C1a C    11.1957   -8.5191
            8   C1y C    16.8345   -9.0748
            9   C1y C    12.3798   -5.1769
            10  O2a O    13.1454  -11.9982
            11  C1y C    11.1965  -11.3021
            12  C1y C    17.9482   -9.8404
            13  O2x O    16.8345   -7.7523
            14  C5x C    11.1965   -4.5505
            15  C1a C    13.5631   -4.5505
            16  C1y C    14.1895  -13.1118
            17  C7x C    10.0132  -10.6757
            18  C1a C    11.1965  -12.6942
            19  C1y C    19.2011   -9.2140
            20  O1a O    17.9482  -11.1629
            21  C1y C    18.0874   -7.1258
            22  C1y C    10.0132   -5.1769
            23  O5x O    11.1965   -3.1584
            24  C1x C    14.1895  -14.5039
            25  O2x O    15.3728  -12.4158
            26  O7x O    10.0132   -9.2836
            27  O6a O     8.9691  -11.5805
            28  C1x C    19.2011   -7.8219
            29  C1a C    18.1570   -5.7337
            30  C1y C    10.0132   -6.5690
            31  C1a C     8.8995   -4.5505
            32  C1z C    15.3728  -15.1304
            33  C1y C    16.4865  -13.1118
            34  C1y C     8.8995   -8.5875
            35  C1z C     8.8995   -7.2650
            36  O1a O    11.1965   -7.2650
            37  C1y C    16.4865  -14.5039
            38  O2a O    15.3728  -16.4529
            39  C1a C    17.6698  -12.4158
            40  C1b C     7.7163   -9.2836
            41  C1a C     7.6467   -7.8219
            42  O1a O     7.6467   -6.5690
            43  O1a O    17.6698  -15.1304
            44  C1a C     7.7163  -10.3973
            45  C1a C    14.7463   -7.9611
            46  C1a C    16.5561  -17.1489
            47  C1a C    14.1199  -15.8264
            48  O2a O    14.2591   -6.0818
            49  C1a C    15.6512   -6.0818
            50  N1c N    20.3843   -9.9100
            51  C1a C    21.6372   -9.2836
            52  C1a C    20.3843  -11.3717
            53  C1c C    32.2700   -9.5900
            54  C1c C    33.4600   -8.9600
            55  C1c C    31.0800   -8.8900
            56  C1b C    29.8200   -9.5900
            57  O1a O    28.6300   -8.8900
            58  O1a O    31.0800   -7.4900
            59  C1c C    34.6500   -9.5900
            60  C6a C    35.9100   -8.8900
            61  O6a O    37.1000   -9.5900
            62  O6a O    35.9100   -7.4900
            63  C1y C    31.0800  -11.7600
            64  O2x O    29.8900  -11.0600
            65  C1y C    31.0800  -13.0900
            66  C1y C    28.7000  -11.7600
            67  C1y C    29.8900  -13.7900
            68  O1a O    32.3400  -13.7900
            69  C1y C    28.7000  -13.0900
            70  C1b C    27.4400  -11.0600
            71  O1a O    29.8900  -15.1900
            72  O1a O    27.4400  -13.7900
            73  O1a O    26.2500  -11.7600
            74  O2a O    32.2700  -11.0600
            75  O1a O    33.4600   -7.4900
            76  O1a O    34.6500  -11.0600
BOND        78
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     3   6 1
            6     3   7 1 #Down
            7     8   4 1 #Down
            8     5   9 1
            9     6  10 1 #Down
            10    6  11 1
            11    8  12 1
            12    8  13 1
            13    9  14 1
            14    9  15 1 #Down
            15   16  10 1 #Down
            16   11  17 1
            17   11  18 1 #Up
            18   12  19 1
            19   12  20 1 #Up
            20   13  21 1
            21   14  22 1
            22   14  23 2
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   21  29 1 #Down
            29   22  30 1
            30   22  31 1 #Up
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   30  35 1
            35   30  36 1 #Up
            36   32  37 1
            37   32  38 1 #Down
            38   33  39 1 #Up
            39   34  40 1 #Down
            40   35  41 1 #Down
            41   35  42 1 #Up
            42   37  43 1 #Down
            43   40  44 1
            44   21  28 1
            45   33  37 1
            46   34  35 1
            47    2  45 1 #Down
            48   38  46 1
            49   32  47 1
            50    2  48 1 #Up
            51   48  49 1
            52   19  50 1 #Down
            53   50  51 1
            54   50  52 1
            55   53  54 1
            56   53  55 1
            57   55  56 1
            58   56  57 1
            59   55  58 1 #Up
            60   54  59 1
            61   59  60 1
            62   60  61 1
            63   60  62 2
            64   63  64 1
            65   63  65 1
            66   64  66 1
            67   65  67 1
            68   65  68 1 #Down
            69   66  69 1
            70   66  70 1 #Up
            71   67  71 1 #Up
            72   69  72 1 #Up
            73   70  73 1
            74   67  69 1
            75   63  74 1 #Up
            76   53  74 1 #Down
            77   54  75 1 #Down
            78   59  76 1 #Down

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