KEGG   DRUG: ClomipramineHelp
Entry
D07727                      Drug                                   

Name
Clomipramine (INN);
Anafranil (TN)
Formula
C19H23ClN2
Exact mass
314.155
Mol weight
314.8523
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01728  Tricyclic antidepressant
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antidepressant, SNRI
Comment
Tricyclic antidepressant, imipramine type
serotonin norepinephrine reuptake inhibitor (SNRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
Serotonergic synapse
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA04 Clomipramine
      D07727  Clomipramine (INN)
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Clomipramine
    D07727  Clomipramine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Clomipramine
      D07727  Clomipramine (INN)
    SLC6A4 (serotonin transporter)
     Clomipramine
      D07727  Clomipramine (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Clomipramine
    D07727  Clomipramine (INN)
 CYP substrates
  CYP1A2
   Clomipramine
    D07727  Clomipramine (INN)
  CYP2C19
   Clomipramine
    D07727  Clomipramine (INN)
  CYP2D6
   Clomipramine
    D07727  Clomipramine (INN)
  CYP3A4
   Clomipramine
    D07727  Clomipramine (INN)
BRITE hierarchy
Other DBs
CAS: 
303-49-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C1x C    23.3100  -21.2100
            2   C8y C    22.4700  -20.0900
            3   C8y C    22.7500  -18.6900
            4   N1y N    24.0800  -18.1300
            5   C1x C    24.7100  -21.2100
            6   C8y C    25.2700  -18.7600
            7   C8y C    25.6200  -20.1600
            8   C8x C    21.7700  -17.7800
            9   C8y C    20.4400  -18.1300
            10  C8x C    20.0900  -19.5300
            11  C8x C    21.0700  -20.4400
            12  C8x C    26.9500  -20.5800
            13  C8x C    28.0000  -19.6700
            14  C8x C    27.7200  -18.2700
            15  C8x C    26.3200  -17.8500
            16  X   Cl   19.3900  -17.1500
            17  C1b C    24.0800  -16.7300
            18  C1b C    25.2700  -16.1000
            19  C1b C    26.4600  -16.8000
            20  N1c N    27.7200  -16.1000
            21  C1a C    28.9100  -16.8700
            22  C1a C    27.7200  -14.7000
BOND        24
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    9  16 1
            19    4  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 1

» Japanese version   » Back

DBGET integrated database retrieval system