KEGG   DRUG: D07734Help
Entry
D07734                      Drug                                   

Name
Cinnarizine dihydrochloride;
Celenid (TN)
Formula
C26H28N2. 2HCl
Exact mass
440.1786
Mol weight
441.4358
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiemetic;
Histamine, H1-receptor antagonist
Remark
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07C ANTIVERTIGO PREPARATIONS
    N07CA Antivertigo preparations
     N07CA02 Cinnarizine
      D07734  Cinnarizine dihydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Cinnarizine [ATC:N07CA02]
      D07734  Cinnarizine dihydrochloride
BRITE hierarchy
Other DBs
CAS: 
7002-58-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C8x C    19.3200  -21.4900
            2   C8x C    19.3200  -22.8900
            3   C8x C    20.5800  -23.5900
            4   C8x C    21.7700  -22.8900
            5   C8y C    21.7700  -21.4900
            6   C8x C    20.5800  -20.7900
            7   C8x C    24.2200  -22.8900
            8   C8y C    24.2200  -21.4900
            9   C1c C    22.9600  -20.7900
            10  C8x C    25.4100  -23.5900
            11  C8x C    26.6000  -22.8900
            12  C8x C    26.6000  -21.4900
            13  C8x C    25.4100  -20.7900
            14  N1y N    22.9600  -19.3200
            15  C1x C    24.2200  -18.6200
            16  C1x C    24.2200  -17.2200
            17  N1y N    22.9600  -16.5200
            18  C1x C    21.7700  -17.2200
            19  C1x C    21.7700  -18.6200
            20  C1b C    22.9600  -15.1200
            21  C2b C    24.2200  -14.4200
            22  C2b C    25.4100  -15.1200
            23  C8y C    26.6000  -14.4200
            24  C8x C    27.7900  -15.1200
            25  C8x C    28.9800  -14.4200
            26  C8x C    28.9800  -13.0200
            27  C8x C    27.7900  -12.3200
            28  C8x C    26.6000  -13.0200
            29  X   Cl   30.1000  -18.2700
            30  X   Cl   30.2400  -21.0700
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22   17  20 1
            23   20  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1

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