KEGG   DRUG: CyclophosphamideHelp
Entry
D07760                      Drug                                   

Name
Cyclophosphamide (INN);
Cyclophosphamide (TN);
Cytoxan (TN)
Formula
C7H15Cl2N2O2P
Exact mass
260.0248
Mol weight
261.086
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01677  Alkylating agent
  DG01678  Nitrogen mustard analogue
   DG01720  Isophosphoramide mustard analogue
Cyp substrate
 DG01638  CYP2A6 substrate
 DG01633  CYP3A4 substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antineoplastic, Alkylating agent
Comment
Active form of prodrug: Phosphoramide mustard [CPD:C07647]
Target
DNA
Metabolism
Enzyme: CYP2A6 [HSA:1548], CYP2B6 [HSA:1555], CYP2C8 [HSA:1558], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antineoplastics - alkylating agents
Immunosuppressive agents
Antirheumatics - DMARDs and biological agents
Other map
Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01A ALKYLATING AGENTS
    L01AA Nitrogen mustard analogues
     L01AA01 Cyclophosphamide
      D07760  Cyclophosphamide (INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Alkylating Agents
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2B6
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
  CYP2C8
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
  CYP2C9
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
  CYP3A4
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
BRITE hierarchy
Other DBs
CAS: 
50-18-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   P1a P    23.6600  -17.8500
            2   N1c N    23.6600  -16.3800
            3   N1x N    24.7800  -18.4800
            4   O2x O    22.5400  -18.4800
            5   O3b O    22.4000  -17.1500
            6   C1b C    22.4000  -15.6800
            7   C1b C    24.9200  -15.6100
            8   C1x C    24.7800  -19.8100
            9   C1x C    22.5400  -19.8100
            10  C1b C    21.1400  -16.5200
            11  C1b C    26.1800  -16.2400
            12  C1x C    23.6600  -20.4400
            13  X   Cl   19.8100  -15.8200
            14  X   Cl   27.4400  -15.4700
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 2
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12   10  13 1
            13   11  14 1
            14    9  12 1

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