| Entry |
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| Name |
Cyclophosphamide (INN);
Cyclophosphamide (TN);
Cytoxan (TN)
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| Formula |
C7H15Cl2N2O2P
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| Exact mass |
260.0248
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| Mol weight |
261.086
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| Structure |
     |
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| Activity |
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| Remark |
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| Comment |
Alkylating agent
Prodrug (See active form, Phosphoramide mustard [CPD: C07647] )
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| Target |
DNA |
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| Metabolism |
Enzyme: CYP2A6 [HSA: 1548], CYP2B6 [HSA: 1555], CYP2C8 [HSA: 1558], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
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| Interaction |
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| Pathway map |
| Drug metabolism - cytochrome P450 |
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| Structure map |
| Antineoplastics - alkylating agents | | Immunosuppressive agents | | Antirheumatics - DMARDs and biological agents |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01A ALKYLATING AGENTS
L01AA Nitrogen mustard analogues
L01AA01 Cyclophosphamide
D07760 Cyclophosphamide (INN)
USP drug classification [BR:br08302]
Antineoplastics
Alkylating Agents
Alkylating Agents, Other
Cyclophosphamide
D07760 Cyclophosphamide (INN)
Antineoplastics [BR:br08308]
Alkylating agents
Nitrogen mustard analogues
Cyclophosphamide [ATC:L01AA01]
D07760 Cyclophosphamide (INN)
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| Other DBs |
CAS: 50-18-0 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 14
1 P1a P 23.6600 -17.8500
2 N1c N 23.6600 -16.3800
3 N1x N 24.7800 -18.4800
4 O2x O 22.5400 -18.4800
5 O3b O 22.4000 -17.1500
6 C1b C 22.4000 -15.6800
7 C1b C 24.9200 -15.6100
8 C1x C 24.7800 -19.8100
9 C1x C 22.5400 -19.8100
10 C1b C 21.1400 -16.5200
11 C1b C 26.1800 -16.2400
12 C1x C 23.6600 -20.4400
13 X Cl 19.8100 -15.8200
14 X Cl 27.4400 -15.4700
BOND 14
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 2
5 2 6 1
6 2 7 1
7 3 8 1
8 4 9 1
9 6 10 1
10 7 11 1
11 8 12 1
12 10 13 1
13 11 14 1
14 9 12 1
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