KEGG   DRUG: D07760Help
Entry
D07760                      Drug                                   

Name
Cyclophosphamide (INN);
Cyclophosphamide (TN);
Cytoxan (TN)
Formula
C7H15Cl2N2O2P
Exact mass
260.0248
Mol weight
261.086
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic, alkylating [DS:H00004 H00005 H00008 H00010 H00011 H00028 H00031 H00035 H00043 H00080]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Alkylating agent
Prodrug, active substance: Phosphoramide mustard [CPD:C07647]
Target
DNA
Metabolism
Enzyme: CYP2A6 [HSA:1548], CYP2B6 [HSA:1555], CYP2C8 [HSA:1558], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antineoplastics - alkylating agents
Immunosuppressive agents
Antirheumatics - DMARDs and biological agents
Other map
Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01A ALKYLATING AGENTS
    L01AA Nitrogen mustard analogues
     L01AA01 Cyclophosphamide
      D07760  Cyclophosphamide (INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Alkylating Agents
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
Antineoplastics [BR:br08308]
 Alkylating agents
  Nitrogen mustard analogues
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2B6
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
  CYP2C8
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
  CYP2C9
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
  CYP3A4
   Cyclophosphamide
    D07760  Cyclophosphamide (INN)
BRITE hierarchy
Other DBs
CAS: 
50-18-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   P1a P    23.6600  -17.8500
            2   N1c N    23.6600  -16.3800
            3   N1x N    24.7800  -18.4800
            4   O2x O    22.5400  -18.4800
            5   O3b O    22.4000  -17.1500
            6   C1b C    22.4000  -15.6800
            7   C1b C    24.9200  -15.6100
            8   C1x C    24.7800  -19.8100
            9   C1x C    22.5400  -19.8100
            10  C1b C    21.1400  -16.5200
            11  C1b C    26.1800  -16.2400
            12  C1x C    23.6600  -20.4400
            13  X   Cl   19.8100  -15.8200
            14  X   Cl   27.4400  -15.4700
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 2
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12   10  13 1
            13   11  14 1
            14    9  12 1

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