KEGG   DRUG: DesvenlafaxineHelp
Entry
D07793                      Drug                                   

Name
Desvenlafaxine (INN)
Product
  Generic
Formula
C16H25NO2
Exact mass
263.1885
Mol weight
263.3752
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: 
Chemical group: 
Activity
Antidepressant, Neurotransmitter antagonist, Serotonin antagonist
Target
serotonin transporter [HSA:6532] [KO:K05037];
noradrenalin transporter [HSA:6530] [KO:K05035]
  Pathway
Serotonergic synapse
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX23 Desvenlafaxine
      D07793  Desvenlafaxine (INN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Desvenlafaxine
    D07793  Desvenlafaxine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Desvenlafaxine
      D07793  Desvenlafaxine (INN)
    SLC6A4 (serotonin transporter)
     Desvenlafaxine
      D07793  Desvenlafaxine (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Desvenlafaxine
    D07793  Desvenlafaxine (INN)
  CYP2D6
   Desvenlafaxine
    D07793  Desvenlafaxine (INN)
Psychiatric agents [br08363.html]
 Antidepressants
  D07793
BRITE hierarchy
Other DBs
CAS: 
93413-62-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        19
            1   C8x C    24.5700  -22.3300
            2   C8y C    24.5700  -23.7300
            3   C8x C    25.7600  -24.4300
            4   C8x C    26.9500  -23.7300
            5   C8y C    26.9500  -22.3300
            6   C8x C    25.7600  -21.6300
            7   C1x C    29.4000  -23.7300
            8   C1z C    29.4000  -22.3300
            9   C1c C    28.1400  -21.6300
            10  C1x C    30.5900  -24.4300
            11  C1x C    31.7800  -23.7300
            12  C1x C    31.7800  -22.3300
            13  C1x C    30.5900  -21.6300
            14  O1a O    23.3800  -24.4300
            15  O1a O    29.3828  -20.9301
            16  C1b C    28.1228  -20.2301
            17  N1c N    26.9149  -19.5524
            18  C1a C    25.6958  -20.2768
            19  C1a C    26.8978  -18.1301
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15    2  14 1
            16    8  15 1
            17    9  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

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