KEGG   DRUG: D07793Help
Entry
D07793                      Drug                                   

Name
Desvenlafaxine (INN)
Product
  Generic
Formula
C16H25NO2
Exact mass
263.1885
Mol weight
263.3752
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant;
Neurotransmitter antagonist;
Serotonin antagonist
Remark
ATC code: 
Drug group: 
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX23 Desvenlafaxine
      D07793  Desvenlafaxine (INN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Desvenlafaxine
    D07793  Desvenlafaxine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Desvenlafaxine
      D07793  Desvenlafaxine (INN)
    SLC6A4 (serotonin transporter)
     Desvenlafaxine
      D07793  Desvenlafaxine (INN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2C19
   Desvenlafaxine
    D07793  Desvenlafaxine (INN)
  CYP2D6
   Desvenlafaxine
    D07793  Desvenlafaxine (INN)
BRITE hierarchy
Other DBs
CAS: 
93413-62-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        19
            1   C8x C    24.5700  -22.3300
            2   C8y C    24.5700  -23.7300
            3   C8x C    25.7600  -24.4300
            4   C8x C    26.9500  -23.7300
            5   C8y C    26.9500  -22.3300
            6   C8x C    25.7600  -21.6300
            7   C1x C    29.4000  -23.7300
            8   C1z C    29.4000  -22.3300
            9   C1c C    28.1400  -21.6300
            10  C1x C    30.5900  -24.4300
            11  C1x C    31.7800  -23.7300
            12  C1x C    31.7800  -22.3300
            13  C1x C    30.5900  -21.6300
            14  O1a O    23.3800  -24.4300
            15  O1a O    29.3828  -20.9301
            16  C1b C    28.1228  -20.2301
            17  N1c N    26.9149  -19.5524
            18  C1a C    25.6958  -20.2768
            19  C1a C    26.8978  -18.1301
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15    2  14 1
            16    8  15 1
            17    9  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

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