KEGG   DRUG: D07803Help
Entry
D07803                      Drug                                   

Name
Dexchlorpheniramine (INN);
d-Chloropheniramine;
Dapriton (TN)
Formula
C16H19ClN2
Exact mass
274.1237
Mol weight
274.7885
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Histamine, H1-receptor antagonist
Remark
Same as: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB02 Dexchlorpheniramine
      D07803  Dexchlorpheniramine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dexchlorpheniramine
      D07803  Dexchlorpheniramine (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Dexchlorpheniramine
    D07803  Dexchlorpheniramine (INN)
  CYP3A4
   Dexchlorpheniramine
    D07803  Dexchlorpheniramine (INN)
  CYP3A5
   Dexchlorpheniramine
    D07803  Dexchlorpheniramine (INN)
  CYP3A7
   Dexchlorpheniramine
    D07803  Dexchlorpheniramine (INN)
 Inhbitors
  CYP2D6
   Dexchlorpheniramine
    D07803  Dexchlorpheniramine (INN)
BRITE hierarchy
Other DBs
CAS: 
25523-97-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8x C    15.4000  -34.3000
            2   C8y C    15.4000  -35.7000
            3   C8x C    16.6124  -36.4000
            4   C8x C    17.8249  -35.7000
            5   C8y C    17.8249  -34.3000
            6   C8x C    16.6124  -33.6000
            7   C1c C    19.0560  -33.5890
            8   C8y C    20.2612  -34.2847
            9   C8x C    20.2616  -35.6996
            10  C8x C    21.4742  -36.3993
            11  C8x C    22.6865  -35.6989
            12  C8x C    22.6860  -34.2839
            13  N5x N    21.4734  -33.5843
            14  X   Cl   14.1876  -36.4000
            15  C1b C    19.0557  -32.2001
            16  C1b C    20.2562  -31.5066
            17  N1c N    20.2561  -30.1002
            18  C1a C    19.0241  -29.3888
            19  C1a C    21.4489  -29.4113
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    2  14 1
            16    7  15 1 #Down
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

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