KEGG   DRUG: D07803Help
Entry
D07803                      Drug                                   

Name
Dexchlorpheniramine (INN);
d-Chloropheniramine;
Dapriton (TN)
Formula
C16H19ClN2
Exact mass
274.1237
Mol weight
274.7885
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Histamine, H1-receptor antagonist
Remark
Same as: 
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB02 Dexchlorpheniramine
      D07803  Dexchlorpheniramine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Dexchlorpheniramine [ATC:R06AB02]
      D07803  Dexchlorpheniramine (INN)
BRITE hierarchy
Other DBs
CAS: 
25523-97-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8x C    15.4000  -34.3000
            2   C8y C    15.4000  -35.7000
            3   C8x C    16.6124  -36.4000
            4   C8x C    17.8249  -35.7000
            5   C8y C    17.8249  -34.3000
            6   C8x C    16.6124  -33.6000
            7   C1c C    19.0560  -33.5890
            8   C8y C    20.2612  -34.2847
            9   C8x C    20.2616  -35.6996
            10  C8x C    21.4742  -36.3993
            11  C8x C    22.6865  -35.6989
            12  C8x C    22.6860  -34.2839
            13  N5x N    21.4734  -33.5843
            14  X   Cl   14.1876  -36.4000
            15  C1b C    19.0557  -32.2001
            16  C1b C    20.2562  -31.5066
            17  N1c N    20.2561  -30.1002
            18  C1a C    19.0241  -29.3888
            19  C1a C    21.4489  -29.4113
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    2  14 1
            16    7  15 1 #Down
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

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