KEGG   DRUG: DexfenfluramineHelp
Entry
D07805                      Drug                                   

Name
Dexfenfluramine (INN)
Formula
C12H16F3N
Exact mass
231.1235
Mol weight
231.2574
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01706  Antiobesity
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: 
Chemical group: 
Activity
Appetite suppressant
Target
serotonin transporter [HSA:6532] [KO:K05037];
serotonin releaser
  Pathway
Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA04 Dexfenfluramine
      D07805  Dexfenfluramine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A3 (dopamine transporter)
     Dexfenfluramine
      D07805  Dexfenfluramine (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Dexfenfluramine
    D07805  Dexfenfluramine (INN)
BRITE hierarchy
Other DBs
CAS: 
3239-44-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C1b C    19.2500  -15.4000
            2   C1c C    20.5100  -16.1000
            3   N1b N    21.7000  -15.4000
            4   C8y C    17.9900  -16.1000
            5   C8x C    16.8000  -15.4700
            6   C8y C    15.6100  -16.1700
            7   C8x C    15.6100  -17.5700
            8   C8x C    16.8000  -18.2000
            9   C8x C    17.9900  -17.5000
            10  C1d C    14.4200  -15.4000
            11  X   F    13.1600  -14.7000
            12  X   F    13.7200  -16.6600
            13  X   F    15.0500  -14.2100
            14  C1a C    20.5100  -17.5000
            15  C1b C    22.8900  -16.1000
            16  C1a C    24.1500  -15.4000
BOND        16
            1     1   2 1
            2     2   3 1
            3     1   4 1
            4     4   5 2
            5     5   6 1
            6     6   7 2
            7     7   8 1
            8     8   9 2
            9     4   9 1
            10    6  10 1
            11   10  11 1
            12   10  12 1
            13   10  13 1
            14    2  14 1 #Up
            15    3  15 1
            16   15  16 1

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