KEGG   DRUG: D07853Help
Entry
D07853                      Drug                                   

Name
Dimetindene (INN);
Dimethindene
Formula
C20H24N2
Exact mass
292.1939
Mol weight
292.418
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Histamine, H1-receptor antagonist
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA13 Dimetindene
      D07853  Dimetindene (INN)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB03 Dimetindene
      D07853  Dimetindene (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dimetindene
      D07853  Dimetindene (INN)
BRITE hierarchy
Other DBs
CAS: 
5636-83-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8x C    19.8100  -18.6900
            2   C8x C    19.8100  -20.0900
            3   C8x C    21.0000  -20.7900
            4   C8x C    21.0000  -17.9900
            5   C8y C    22.2600  -18.6900
            6   C8y C    22.2600  -20.0900
            7   C1x C    23.5900  -20.5800
            8   C2y C    24.3600  -19.3900
            9   C2y C    23.5900  -18.2700
            10  C1b C    25.7600  -19.3900
            11  C1b C    26.4600  -20.6500
            12  N1c N    27.8600  -20.6500
            13  C1a C    28.5600  -21.8400
            14  C1a C    28.5600  -19.4600
            15  C1c C    23.5900  -16.8700
            16  C8y C    24.7800  -16.1700
            17  C1a C    22.3300  -16.1700
            18  C8x C    25.9700  -16.8700
            19  C8x C    27.1600  -16.1700
            20  C8x C    27.1600  -14.7700
            21  C8x C    25.9700  -14.0700
            22  N5x N    24.7800  -14.7700
BOND        24
            1    12  14 1
            2     2   3 1
            3     9  15 1
            4     3   6 2
            5    15  16 1
            6     5   6 1
            7    15  17 1
            8     6   7 1
            9     7   8 1
            10    8   9 2
            11    9   5 1
            12    5   4 2
            13   16  18 2
            14   18  19 1
            15   19  20 2
            16   20  21 1
            17   21  22 2
            18   22  16 1
            19    8  10 1
            20    4   1 1
            21   10  11 1
            22   11  12 1
            23   12  13 1
            24    1   2 2

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