KEGG   DRUG: D07854Help
Entry
D07854                      Drug                                   

Name
Dimetotiazine (INN);
Fonazine;
Migristene (TN)
Formula
C19H25N3O2S2
Exact mass
391.1388
Mol weight
391.5507
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Serotonin antagonist;
Histamine, H1-receptor antagonist;
Antimigraine
Remark
ATC code: 
Drug group: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
histamine H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Interaction
Drug interaction
Structure map
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CX Other antimigraine preparations
     N02CX05 Dimetotiazine
      D07854  Dimetotiazine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dimetotiazine
      D07854  Dimetotiazine (INN)
   Serotonin
    5-HT2-receptor
     Dimetotiazine
      D07854  Dimetotiazine (INN)
BRITE hierarchy
Other DBs
CAS: 
7456-24-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   S2x S    22.3300  -21.4200
            2   N1y N    22.3300  -18.6200
            3   C8y C    23.5900  -19.3200
            4   C8y C    23.5900  -20.7200
            5   C8x C    24.7800  -21.4200
            6   C8x C    25.9700  -20.7200
            7   C8y C    25.9700  -19.3200
            8   C8x C    24.7800  -18.6200
            9   C8y C    21.1400  -20.7200
            10  C8y C    21.1400  -19.3200
            11  C8x C    19.9500  -18.6200
            12  C8x C    18.6900  -19.3200
            13  C8x C    18.6900  -20.7200
            14  C8x C    19.9500  -21.4200
            15  C1b C    22.3300  -17.2200
            16  C1c C    23.5900  -16.5200
            17  C1a C    24.7800  -17.2200
            18  N1c N    23.5900  -15.1200
            19  C1a C    24.7800  -14.4200
            20  C1a C    22.3300  -14.4200
            21  S4a S    27.2300  -18.6200
            22  N1c N    28.4200  -19.3200
            23  O3c O    28.2100  -17.6400
            24  O3c O    26.2500  -17.6400
            25  C1a C    29.6100  -18.6900
            26  C1a C    28.4200  -20.7900
BOND        28
            1     1   4 1
            2     9  10 2
            3    10  11 1
            4    11  12 2
            5    12  13 1
            6    13  14 2
            7    14   9 1
            8     3   2 1
            9     2  15 1
            10    3   4 2
            11   15  16 1
            12    4   5 1
            13    5   6 2
            14   16  17 1
            15   16  18 1
            16    6   7 1
            17   18  19 1
            18    7   8 2
            19   18  20 1
            20    8   3 1
            21    2  10 1
            22    9   1 1
            23    7  21 1
            24   21  22 1
            25   21  23 2
            26   21  24 2
            27   22  25 1
            28   22  26 1

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