KEGG   DRUG: D07860Help
Entry
D07860                      Drug                                   

Name
Dioxopromethazine hydrochloride;
Prothanon gel (TN)
Formula
C17H20N2O2S. xHCl
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Histamine, H1-receptor antagonist, Antihistaminic
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dioxopromethazine
      D07860  Dioxopromethazine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
13754-57-9
PubChem: 
LigandBox: 
KCF data Show

ATOM        23
            1   C8x C    20.5100  -18.8300
            2   C8x C    20.5100  -20.2300
            3   C8x C    21.7000  -20.9300
            4   C8y C    22.9600  -20.2300
            5   C8y C    22.9600  -18.8300
            6   C8x C    21.7000  -18.1300
            7   S2x S    24.1500  -20.9300
            8   C8y C    25.3400  -20.2300
            9   C8y C    25.3400  -18.8300
            10  N4y N    24.1500  -18.1300
            11  C8x C    26.6000  -20.9300
            12  C8x C    27.7900  -20.2300
            13  C8x C    27.7900  -18.8300
            14  C8x C    26.6000  -18.1300
            15  O3c O    23.1700  -21.9100
            16  O3c O    25.1300  -21.9100
            17  C1b C    24.1500  -16.7300
            18  C1c C    25.3400  -16.0300
            19  C1a C    26.6000  -16.7300
            20  N1c N    25.3400  -14.6300
            21  C1a C    26.6000  -13.9300
            22  C1a C    24.1500  -13.9300
            23  X   Cl   30.9400  -19.1100
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17    7  15 2
            18    7  16 2
            19   10  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 1
            23   20  21 1
            24   20  22 1
BRACKET     1    29.4700  -19.8800   29.4700  -18.2000
            1    32.1300  -18.2000   32.1300  -19.8800
            1  x
 ORIGINAL  1   23
 REPEAT    1

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