KEGG   DRUG: DonepezilHelp
Entry
D07869                      Drug                                   

Name
Donepezil (INN);
Donaz (TN)
Formula
C24H29NO3
Exact mass
379.2147
Mol weight
379.492
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Remark
ATC code: 
Chemical group: 
Activity
Nootropic, Acetylcholinesterase inhibitor
Target
acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
  Pathway
Glycerophospholipid metabolism
Cholinergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA02 Donepezil
      D07869  Donepezil (INN)
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Donepezil
    D07869  Donepezil (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Donepezil
     D07869  Donepezil (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Donepezil
    D07869  Donepezil (INN)
  CYP3A4
   Donepezil
    D07869  Donepezil (INN)
BRITE hierarchy
Other DBs
CAS: 
120014-06-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    26.5300  -17.3600
            2   C8x C    26.5300  -18.7600
            3   C8x C    27.7200  -19.4600
            4   C8x C    28.9100  -18.7600
            5   C8x C    28.9100  -17.3600
            6   C8x C    27.7200  -16.6600
            7   C1b C    25.2700  -16.6600
            8   N1y N    24.0800  -17.3600
            9   C1x C    22.8900  -16.6600
            10  C1x C    21.7000  -17.3600
            11  C1y C    21.7000  -18.7600
            12  C1x C    22.8900  -19.4600
            13  C1x C    24.0800  -18.7600
            14  C1b C    20.4400  -19.4600
            15  C1y C    19.2500  -18.7600
            16  C5x C    19.2500  -17.3600
            17  C8y C    17.9900  -16.8700
            18  C8y C    17.0800  -17.9900
            19  C1x C    17.9200  -19.1800
            20  O5x O    20.4400  -16.5900
            21  C8x C    17.4300  -15.5400
            22  C8y C    16.0300  -15.3300
            23  C8y C    15.1900  -16.4500
            24  C8x C    15.6800  -17.7800
            25  O2a O    15.5400  -14.0700
            26  C1a C    14.2100  -14.0700
            27  O2a O    13.8600  -16.4500
            28  C1a C    13.0900  -15.2600
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   15  19 1
            22   16  20 2
            23   17  21 2
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   18  24 2
            28   22  25 1
            29   25  26 1
            30   23  27 1
            31   27  28 1

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