KEGG   DRUG: D07869Help
Entry
D07869                      Drug                                   

Name
Donepezil (INN);
Donaz (TN)
Formula
C24H29NO3
Exact mass
379.2147
Mol weight
379.492
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Nootropic [DS:H00056]
Remark
ATC code: 
Drug group: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA02 Donepezil
      D07869  Donepezil (INN)
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Donepezil
    D07869  Donepezil (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Donepezil
     D07869  Donepezil (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Donepezil
    D07869  Donepezil (INN)
  CYP3A4
   Donepezil
    D07869  Donepezil (INN)
BRITE hierarchy
Other DBs
CAS: 
120014-06-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    26.5300  -17.3600
            2   C8x C    26.5300  -18.7600
            3   C8x C    27.7200  -19.4600
            4   C8x C    28.9100  -18.7600
            5   C8x C    28.9100  -17.3600
            6   C8x C    27.7200  -16.6600
            7   C1b C    25.2700  -16.6600
            8   N1y N    24.0800  -17.3600
            9   C1x C    22.8900  -16.6600
            10  C1x C    21.7000  -17.3600
            11  C1y C    21.7000  -18.7600
            12  C1x C    22.8900  -19.4600
            13  C1x C    24.0800  -18.7600
            14  C1b C    20.4400  -19.4600
            15  C1y C    19.2500  -18.7600
            16  C5x C    19.2500  -17.3600
            17  C8y C    17.9900  -16.8700
            18  C8y C    17.0800  -17.9900
            19  C1x C    17.9200  -19.1800
            20  O5x O    20.4400  -16.5900
            21  C8x C    17.4300  -15.5400
            22  C8y C    16.0300  -15.3300
            23  C8y C    15.1900  -16.4500
            24  C8x C    15.6800  -17.7800
            25  O2a O    15.5400  -14.0700
            26  C1a C    14.2100  -14.0700
            27  O2a O    13.8600  -16.4500
            28  C1a C    13.0900  -15.2600
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   15  19 1
            22   16  20 2
            23   17  21 2
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   18  24 2
            28   22  25 1
            29   25  26 1
            30   23  27 1
            31   27  28 1

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