KEGG   DRUG: D07874Help
Entry
D07874                      Drug                                   

Name
Doxazosin (INN);
Cardura XL (TN)
Formula
C23H25N5O5
Exact mass
451.1856
Mol weight
451.4751
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Same as: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CA Alpha-adrenoreceptor antagonists
     C02CA04 Doxazosin
      D07874  Doxazosin (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Blocking Agents
   Doxazosin
    D07874  Doxazosin (INN)
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Doxazosin
    D07874  Doxazosin (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Doxazosin
      D07874  Doxazosin (INN)
BRITE hierarchy
Other DBs
CAS: 
74191-85-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C8y C    28.3500  -18.2700
            2   C8y C    28.3500  -19.6700
            3   N5x N    27.1600  -17.5700
            4   C8x C    29.6100  -17.5700
            5   C8x C    29.5400  -20.3700
            6   C8y C    27.1600  -20.3700
            7   C8y C    25.9700  -18.2700
            8   C8y C    30.8000  -18.2700
            9   C8y C    30.8000  -19.6700
            10  N5x N    25.9700  -19.6700
            11  N1a N    27.1600  -21.7700
            12  N1y N    24.7100  -17.5700
            13  O2a O    31.9900  -17.5700
            14  O2a O    31.9900  -20.3700
            15  C1x C    23.5200  -18.2700
            16  C1x C    24.7100  -16.1700
            17  C1a C    33.2500  -18.2700
            18  C1a C    33.1800  -19.6700
            19  C1x C    22.3300  -17.5700
            20  C1x C    23.5200  -15.4700
            21  N1y N    22.3300  -16.1700
            22  C5a C    21.1400  -15.4700
            23  C1y C    19.8800  -16.1700
            24  O5a O    21.1400  -14.0700
            25  O2x O    18.6900  -15.4700
            26  C1x C    19.8800  -17.5700
            27  C8y C    17.4300  -16.1700
            28  O2x O    18.6900  -18.2700
            29  C8y C    17.4300  -17.5700
            30  C8x C    16.2400  -15.4700
            31  C8x C    16.2400  -18.2700
            32  C8x C    15.0500  -16.1700
            33  C8x C    15.0500  -17.5700
BOND        37
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   12  15 1
            15   12  16 1
            16   13  17 1
            17   14  18 1
            18   15  19 1
            19   16  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 1
            25   23  26 1
            26   25  27 1
            27   26  28 1
            28   27  29 1
            29   27  30 2
            30   29  31 2
            31   30  32 1
            32   31  33 1
            33    7  10 2
            34    8   9 1
            35   20  21 1
            36   28  29 1
            37   32  33 2

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