KEGG   DRUG: D07876Help
Entry
D07876                      Drug                                   

Name
Doxycycline (INN);
DOXY;
Doxychel (TN);
Doxycycline (TN)
Formula
C22H24N2O8
Exact mass
444.1533
Mol weight
444.4346
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, tetracycline [DS:H00310 H00322]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
See Doxycycline [DR:D00307]
Semisynthetic tetracycline
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB22 Doxycycline
      D07876  Doxycycline (INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA02 Doxycycline
      D07876  Doxycycline (INN)
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Doxycycline
    D07876  Doxycycline (INN)
 Dental and Oral Agents
  Doxycycline
   D07876  Doxycycline (INN)
 Dermatological Agents
  Doxycycline
   D07876  Doxycycline (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Doxycycline
      D07876  Doxycycline (INN)
BRITE hierarchy
Other DBs
CAS: 
564-25-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C1y C    25.3288  -17.9821
            2   C1z C    25.3288  -19.3115
            3   C1y C    26.5183  -17.3524
            4   C1y C    24.1394  -17.2824
            5   C2y C    24.1394  -20.0112
            6   C5x C    26.4483  -20.0112
            7   C2y C    27.6378  -18.0520
            8   C1y C    23.0199  -17.9821
            9   C2y C    23.0199  -19.3115
            10  O1a O    24.1394  -21.3406
            11  C2y C    27.6378  -19.3815
            12  O5x O    26.4483  -21.4106
            13  O1a O    28.8273  -17.3524
            14  C1y C    21.8304  -17.2824
            15  C5x C    21.8304  -20.0112
            16  C5a C    28.8273  -20.0811
            17  C8y C    20.6409  -17.9821
            18  C8y C    20.6409  -19.3115
            19  O5x O    21.8304  -21.3406
            20  N1a N    30.0168  -19.3815
            21  O5a O    28.8273  -21.4106
            22  C8x C    19.4514  -17.2824
            23  C8y C    19.4514  -20.0112
            24  C8x C    18.2620  -17.9821
            25  C8x C    18.2620  -19.3115
            26  O1a O    19.4514  -21.3406
            27  C1a C    21.8304  -15.6031
            28  N1c N    26.5183  -15.1133
            29  C1a C    27.7078  -14.4836
            30  C1a C    25.3288  -14.4136
            31  O1a O    24.1394  -15.6031
            32  O1a O    25.3288  -20.7109
BOND        35
            1     5   9 2
            2     5  10 1
            3     6  11 1
            4     6  12 2
            5     7  13 1
            6     8  14 1
            7     9  15 1
            8    11  16 1
            9    14  17 1
            10   15  18 1
            11   15  19 2
            12   16  20 1
            13   16  21 2
            14   17  22 1
            15   18  23 1
            16   22  24 2
            17   23  25 2
            18   23  26 1
            19    7  11 2
            20    8   9 1
            21   17  18 2
            22   24  25 1
            23   14  27 1 #Down
            24    3  28 1 #Down
            25    1   2 1
            26   28  29 1
            27    1   3 1
            28   28  30 1
            29    1   4 1
            30    2   5 1
            31    2   6 1
            32    4  31 1 #Down
            33    3   7 1
            34    2  32 1 #Down
            35    4   8 1

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