KEGG   DRUG: EfonidipineHelp
Entry
D07886                      Drug                                   

Name
Efonidipine (INN)
Formula
C34H38N3O7P
Exact mass
631.2447
Mol weight
631.6552
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
  DG01573  Calcium channel T type blocker
Remark
Chemical group: 
Activity
Antihypertensive, Vasodilator, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Efonidipine
      D07886  Efonidipine (INN)
    calcium channel T type
     Efonidipine
      D07886  Efonidipine (INN)
BRITE hierarchy
Other DBs
CAS: 
111011-63-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        45
            1   C1y C    21.2100  -16.5900
            2   C2y C    22.4000  -15.8900
            3   C2y C    19.9500  -15.8900
            4   C8y C    21.2100  -17.9900
            5   C2y C    22.4000  -14.4900
            6   C7a C    23.5900  -16.5900
            7   C2y C    19.9500  -14.4900
            8   P1b P    18.7600  -16.5900
            9   C8x C    22.4000  -18.6900
            10  C8x C    19.9500  -18.6900
            11  N1x N    21.2100  -13.7900
            12  C1a C    23.5900  -13.7200
            13  O7a O    24.7800  -15.8900
            14  O6a O    23.5900  -17.9900
            15  C1a C    18.7600  -13.7900
            16  C8y C    22.4000  -20.0900
            17  C8x C    19.9500  -20.0900
            18  C1b C    26.0400  -16.5900
            19  C8x C    21.2100  -20.7900
            20  N2b N    23.5900  -20.7900 #+
            21  C1b C    27.2300  -15.8200
            22  O3a O    24.9900  -19.9500
            23  O3a O    23.5900  -22.1900 #-
            24  O2x O    18.7600  -17.9900
            25  C1x C    17.5000  -18.6900
            26  C1z C    16.3100  -17.9900
            27  C1x C    16.3100  -16.5900
            28  O2x O    17.5700  -15.8900
            29  O3b O    18.7600  -15.1900
            30  N1c N    28.4200  -16.5200
            31  C1b C    29.6800  -15.8900
            32  C8y C    30.8700  -16.5200
            33  C8x C    32.0600  -15.8900
            34  C8x C    33.2500  -16.5900
            35  C8x C    33.2500  -17.9200
            36  C8x C    32.0600  -18.6200
            37  C8x C    30.8700  -17.9200
            38  C8y C    28.4200  -17.9200
            39  C8x C    29.6100  -18.6200
            40  C8x C    29.6100  -20.0200
            41  C8x C    28.4200  -20.7200
            42  C8x C    27.2300  -20.0200
            43  C8x C    27.2300  -18.6200
            44  C1a C    15.0500  -18.6900
            45  C1a C    15.1200  -17.2900
BOND        49
            1    20  22 2
            2    20  23 1
            3     7  11 1
            4    17  19 2
            5     1   2 1
            6     1   3 1
            7     1   4 1
            8     8  24 1
            9    24  25 1
            10   25  26 1
            11   26  27 1
            12   27  28 1
            13   28   8 1
            14    2   5 2
            15    8  29 2
            16    2   6 1
            17    3   7 2
            18    3   8 1
            19   21  30 1
            20    4   9 1
            21   30  31 1
            22    4  10 2
            23   31  32 1
            24    5  11 1
            25    5  12 1
            26    6  13 1
            27    6  14 2
            28    7  15 1
            29   32  33 2
            30   33  34 1
            31   34  35 2
            32   35  36 1
            33   36  37 2
            34   37  32 1
            35    9  16 2
            36   30  38 1
            37   10  17 1
            38   13  18 1
            39   16  19 1
            40   16  20 1
            41   18  21 1
            42   38  39 2
            43   39  40 1
            44   40  41 2
            45   41  42 1
            46   42  43 2
            47   43  38 1
            48   26  44 1
            49   26  45 1

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