KEGG   DRUG: D07886Help
Entry
D07886                      Drug                                   

Name
Efonidipine (INN)
Formula
C34H38N3O7P
Exact mass
631.2447
Mol weight
631.6552
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive;
Calcium antagonist
Remark
Drug group: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Efonidipine
      D07886  Efonidipine (INN)
    calcium channel T type
     Efonidipine
      D07886  Efonidipine (INN)
BRITE hierarchy
Other DBs
CAS: 
111011-63-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        45
            1   C1y C    21.2100  -16.5900
            2   C2y C    22.4000  -15.8900
            3   C2y C    19.9500  -15.8900
            4   C8y C    21.2100  -17.9900
            5   C2y C    22.4000  -14.4900
            6   C7a C    23.5900  -16.5900
            7   C2y C    19.9500  -14.4900
            8   P1b P    18.7600  -16.5900
            9   C8x C    22.4000  -18.6900
            10  C8x C    19.9500  -18.6900
            11  N1x N    21.2100  -13.7900
            12  C1a C    23.5900  -13.7200
            13  O7a O    24.7800  -15.8900
            14  O6a O    23.5900  -17.9900
            15  C1a C    18.7600  -13.7900
            16  C8y C    22.4000  -20.0900
            17  C8x C    19.9500  -20.0900
            18  C1b C    26.0400  -16.5900
            19  C8x C    21.2100  -20.7900
            20  N2b N    23.5900  -20.7900 #+
            21  C1b C    27.2300  -15.8200
            22  O3a O    24.9900  -19.9500
            23  O3a O    23.5900  -22.1900 #-
            24  O2x O    18.7600  -17.9900
            25  C1x C    17.5000  -18.6900
            26  C1z C    16.3100  -17.9900
            27  C1x C    16.3100  -16.5900
            28  O2x O    17.5700  -15.8900
            29  O3b O    18.7600  -15.1900
            30  N1c N    28.4200  -16.5200
            31  C1b C    29.6800  -15.8900
            32  C8y C    30.8700  -16.5200
            33  C8x C    32.0600  -15.8900
            34  C8x C    33.2500  -16.5900
            35  C8x C    33.2500  -17.9200
            36  C8x C    32.0600  -18.6200
            37  C8x C    30.8700  -17.9200
            38  C8y C    28.4200  -17.9200
            39  C8x C    29.6100  -18.6200
            40  C8x C    29.6100  -20.0200
            41  C8x C    28.4200  -20.7200
            42  C8x C    27.2300  -20.0200
            43  C8x C    27.2300  -18.6200
            44  C1a C    15.0500  -18.6900
            45  C1a C    15.1200  -17.2900
BOND        49
            1    20  22 2
            2    20  23 1
            3     7  11 1
            4    17  19 2
            5     1   2 1
            6     1   3 1
            7     1   4 1
            8     8  24 1
            9    24  25 1
            10   25  26 1
            11   26  27 1
            12   27  28 1
            13   28   8 1
            14    2   5 2
            15    8  29 2
            16    2   6 1
            17    3   7 2
            18    3   8 1
            19   21  30 1
            20    4   9 1
            21   30  31 1
            22    4  10 2
            23   31  32 1
            24    5  11 1
            25    5  12 1
            26    6  13 1
            27    6  14 2
            28    7  15 1
            29   32  33 2
            30   33  34 1
            31   34  35 2
            32   35  36 1
            33   36  37 2
            34   37  32 1
            35    9  16 2
            36   30  38 1
            37   10  17 1
            38   13  18 1
            39   16  19 1
            40   16  20 1
            41   18  21 1
            42   38  39 2
            43   39  40 1
            44   40  41 2
            45   41  42 1
            46   42  43 2
            47   43  38 1
            48   26  44 1
            49   26  45 1

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