KEGG   DRUG: EncainideHelp
Entry
D07894                      Drug                                   

Name
Encainide (INN)
Formula
C22H28N2O2
Exact mass
352.2151
Mol weight
352.4699
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C06978
ATC code: C01BC08
Chemical structure group: DG00203
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC08 Encainide
      D07894  Encainide (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D07894  Encainide (INN)
    SCN2A
     D07894  Encainide (INN)
    SCN3A
     D07894  Encainide (INN)
    SCN4A
     D07894  Encainide (INN)
    SCN5A
     D07894  Encainide (INN)
    SCN8A
     D07894  Encainide (INN)
    SCN9A
     D07894  Encainide (INN)
    SCN10A
     D07894  Encainide (INN)
    SCN11A
     D07894  Encainide (INN)
BRITE hierarchy
Other DBs
CAS: 37612-13-8
PubChem: 96024590
ChEBI: 4788
ChEMBL: CHEMBL315838
DrugBank: DB01228
LigandBox: D07894
NIKKAJI: J1.621.570H
KCF data Show

ATOM        26
            1   C8y C    25.4100  -18.9700
            2   C8y C    26.6000  -18.2700
            3   N1b N    24.2200  -18.2700
            4   C8x C    25.4100  -20.3700
            5   C1b C    26.6000  -16.8700
            6   C8x C    27.8600  -18.9700
            7   C5a C    22.9600  -18.9700
            8   C8x C    26.6000  -21.0700
            9   C1b C    27.8600  -16.1700
            10  C8x C    27.8600  -20.3700
            11  C8y C    21.7700  -18.2700
            12  O5a O    22.9600  -20.3700
            13  C1y C    29.0500  -16.8700
            14  C8x C    20.5800  -18.9700
            15  C8x C    21.7700  -16.9400
            16  C1x C    29.0500  -18.2700
            17  N1y N    30.2400  -16.1700
            18  C8x C    19.3900  -18.3400
            19  C8x C    20.5800  -16.2400
            20  C1x C    30.2400  -18.9700
            21  C1x C    31.5000  -16.8700
            22  C8y C    19.3900  -16.9400
            23  C1x C    31.5000  -18.2700
            24  O2a O    18.0600  -16.2400
            25  C1a C    16.8700  -16.9400
            26  C1a C    30.1700  -14.7700
BOND        28
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 2
            10    7  11 1
            11    7  12 2
            12    9  13 1
            13   11  14 2
            14   11  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   15  19 2
            19   16  20 1
            20   17  21 1
            21   18  22 2
            22   20  23 1
            23   22  24 1
            24   24  25 1
            25    8  10 1
            26   19  22 1
            27   21  23 1
            28   17  26 1

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