KEGG   DRUG: D07894Help
Entry
D07894                      Drug                                   

Name
Encainide (INN)
Formula
C22H28N2O2
Exact mass
352.2151
Mol weight
352.4699
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic
Remark
Same as: 
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC08 Encainide
      D07894  Encainide (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Encainide
      D07894  Encainide (INN)
    voltage-gated sodium channel (SCN2A)
     Encainide
      D07894  Encainide (INN)
    voltage-gated sodium channel (SCN3A)
     Encainide
      D07894  Encainide (INN)
    voltage-gated sodium channel (SCN4A)
     Encainide
      D07894  Encainide (INN)
    voltage-gated sodium channel (SCN5A)
     Encainide
      D07894  Encainide (INN)
    voltage-gated sodium channel (SCN8A)
     Encainide
      D07894  Encainide (INN)
    voltage-gated sodium channel (SCN9A)
     Encainide
      D07894  Encainide (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Encainide
    D07894  Encainide (INN)
BRITE hierarchy
Other DBs
CAS: 
37612-13-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8y C    25.4100  -18.9700
            2   C8y C    26.6000  -18.2700
            3   N1b N    24.2200  -18.2700
            4   C8x C    25.4100  -20.3700
            5   C1b C    26.6000  -16.8700
            6   C8x C    27.8600  -18.9700
            7   C5a C    22.9600  -18.9700
            8   C8x C    26.6000  -21.0700
            9   C1b C    27.8600  -16.1700
            10  C8x C    27.8600  -20.3700
            11  C8y C    21.7700  -18.2700
            12  O5a O    22.9600  -20.3700
            13  C1y C    29.0500  -16.8700
            14  C8x C    20.5800  -18.9700
            15  C8x C    21.7700  -16.9400
            16  C1x C    29.0500  -18.2700
            17  N1y N    30.2400  -16.1700
            18  C8x C    19.3900  -18.3400
            19  C8x C    20.5800  -16.2400
            20  C1x C    30.2400  -18.9700
            21  C1x C    31.5000  -16.8700
            22  C8y C    19.3900  -16.9400
            23  C1x C    31.5000  -18.2700
            24  O2a O    18.0600  -16.2400
            25  C1a C    16.8700  -16.9400
            26  C1a C    30.1700  -14.7700
BOND        28
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 2
            10    7  11 1
            11    7  12 2
            12    9  13 1
            13   11  14 2
            14   11  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   15  19 2
            19   16  20 1
            20   17  21 1
            21   18  22 2
            22   20  23 1
            23   22  24 1
            24   24  25 1
            25    8  10 1
            26   19  22 1
            27   21  23 1
            28   17  26 1

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