KEGG   DRUG: D07901Help
Entry
D07901                      Drug                                   

Name
Epirubicin (INN);
Farmorubicin (TN)
Formula
C27H29NO11
Exact mass
543.1741
Mol weight
543.5193
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Streptomyces peucetius [TAX:1950]
Activity
Antineoplastic;
Antibiotic [DS:H00031]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
semisynthetic
Indications: Node tumor, primary breast cancer
Target
topoisomerase II inhibitor [HSA:7153 7155] [KO:K03164]
Interaction
Drug interaction
Structure map
Antineoplastics - agents from natural products
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DB Anthracyclines and related substances
     L01DB03 Epirubicin
      D07901  Epirubicin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Isomerases
   topoisomerase II
    Epirubicin
     D07901  Epirubicin (INN)
Antineoplastics [BR:br08308]
 Natural products
  Antibiotics
   Epirubicin
    D07901  Epirubicin (INN)
BRITE hierarchy
Other DBs
CAS: 
56420-45-2
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        39
            1   C8x C    17.5000  -15.1200
            2   C8x C    17.5000  -16.5200
            3   C8y C    18.6900  -17.2200
            4   C8y C    19.9500  -16.5200
            5   C8y C    19.9500  -15.1200
            6   C8x C    18.6900  -14.4200
            7   C5x C    21.1400  -17.2200
            8   C8y C    22.3300  -16.5200
            9   C8y C    22.3300  -15.1200
            10  C5x C    21.1400  -14.4200
            11  C8y C    23.5900  -17.2200
            12  C8y C    24.7800  -16.5200
            13  C8y C    24.7800  -15.1200
            14  C8y C    23.5900  -14.4200
            15  C1y C    25.9700  -17.2200
            16  C1x C    27.2300  -16.5200
            17  C1z C    27.2300  -15.1200
            18  C1x C    25.9700  -14.4200
            19  O2a O    18.6900  -18.6200
            20  C1a C    17.5000  -19.3200
            21  O5x O    21.1400  -18.6200
            22  O5x O    21.1400  -13.0200
            23  O1a O    23.5900  -13.0200
            24  O1a O    23.5900  -18.6200
            25  O2a O    25.9700  -18.6200
            26  C1y C    27.1600  -19.3200
            27  C5a C    28.4200  -14.4200
            28  C1b C    29.6100  -15.1200
            29  O1a O    30.8000  -14.4200
            30  O5a O    28.4200  -13.0200
            31  O1a O    28.4200  -15.8200
            32  C1x C    27.1600  -20.7200
            33  C1y C    28.4200  -21.4200
            34  C1y C    29.6100  -20.7200
            35  C1y C    29.6100  -19.3200
            36  O2x O    28.4200  -18.6200
            37  N1a N    28.4200  -22.8200
            38  C1a C    30.8000  -18.6200
            39  O1a O    30.8000  -21.4200
BOND        43
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   12  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   13  18 1
            22    3  19 1
            23   19  20 1
            24    7  21 2
            25   10  22 2
            26   14  23 1
            27   11  24 1
            28   26  25 1 #Down
            29   15  25 1 #Down
            30   17  27 1 #Up
            31   27  28 1
            32   28  29 1
            33   27  30 2
            34   17  31 1 #Down
            35   26  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   35  36 1
            40   26  36 1
            41   33  37 1 #Up
            42   35  38 1 #Up
            43   34  39 1 #Down

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