KEGG   DRUG: D07909Help
Entry
D07909                      Drug                                   

Name
Erythromycin thiocyanate;
Erythrocin (TN)
Formula
C37H67NO13. CHNS
Exact mass
792.4442
Mol weight
793.0171
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, macrolide
Remark
ATC code: 
Drug group: 
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D07909  Erythromycin thiocyanate
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D07909  Erythromycin thiocyanate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Erythromycin
      D07909  Erythromycin thiocyanate
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Erythromycin
    D07909  Erythromycin thiocyanate
  CYP3A5
   Erythromycin
    D07909  Erythromycin thiocyanate
  CYP3A7
   Erythromycin
    D07909  Erythromycin thiocyanate
 Inhbitors
  CYP2C19
   Erythromycin
    D07909  Erythromycin thiocyanate
  CYP3A4
   Erythromycin
    D07909  Erythromycin thiocyanate
  CYP3A7
   Erythromycin
    D07909  Erythromycin thiocyanate
  CYP3A
   Erythromycin
    D07909  Erythromycin thiocyanate
BRITE hierarchy
Other DBs
CAS: 
7704-67-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        54
            1   C1y C    17.3600  -16.5900
            2   C1z C    17.3600  -15.2600
            3   C1y C    16.1700  -17.2900
            4   O2a O    19.3200  -17.2900
            5   C1x C    16.1700  -14.5600
            6   O1a O    18.4100  -14.2800
            7   C1a C    18.6200  -15.6800
            8   C1y C    16.1700  -18.6200
            9   C1a C    15.1900  -16.2400
            10  C1y C    20.9300  -16.5900
            11  C1y C    16.1700  -13.1600
            12  O2a O    16.9400  -20.0200
            13  C1y C    14.9800  -19.3200
            14  C1y C    22.1200  -17.2900
            15  O2x O    20.9300  -15.2600
            16  C5x C    14.9800  -12.5300
            17  C1a C    17.3600  -12.5300
            18  C1y C    18.4100  -20.4400
            19  C7x C    13.7900  -18.6200
            20  C1a C    14.9800  -20.7200
            21  C1y C    23.2400  -16.6600
            22  O1a O    22.0500  -18.6900
            23  C1y C    22.1200  -14.5600
            24  C1y C    13.7900  -13.1600
            25  O5x O    14.9800  -11.1300
            26  C1x C    18.4100  -21.7700
            27  O2x O    19.6000  -19.7400
            28  O7x O    13.7900  -17.2900
            29  O6a O    12.7400  -19.6000
            30  C1x C    23.3100  -15.2600
            31  N1c N    24.4300  -17.3600
            32  C1a C    22.1200  -13.2300
            33  C1y C    13.7900  -14.5600
            34  C1a C    12.6700  -12.5300
            35  C1z C    19.6000  -22.4700
            36  C1y C    20.7900  -20.4400
            37  C1y C    12.6700  -16.5900
            38  C1z C    12.6700  -15.2600
            39  O1a O    14.9800  -15.2600
            40  C1y C    20.7900  -21.7700
            41  O2a O    19.6000  -23.8000
            42  C1a C    21.0700  -23.4500
            43  C1a C    21.9800  -19.7400
            44  C1b C    11.4800  -17.2900
            45  C1a C    11.4100  -15.8200
            46  O1a O    11.4100  -14.5600
            47  O1a O    21.9800  -22.4700
            48  C1a C    20.7200  -24.7800
            49  C1a C    11.4800  -18.4100
            50  C1a C    25.6900  -16.5900
            51  C1a C    24.4300  -18.6900
            52  C3b C    31.6400  -18.1300
            53  N3a N    33.0400  -18.1300
            54  S1a S    30.2400  -18.1300
BOND        55
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   31  51 1
            54   52  53 3
            55   52  54 1

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