KEGG   DRUG: D07909Help
Entry
D07909                      Drug                                   

Name
Erythromycin thiocyanate;
Erythrocin (TN)
Formula
C37H67NO13. CHNS
Exact mass
792.4442
Mol weight
793.0171
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, macrolide
Remark
ATC code: 
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D07909  Erythromycin thiocyanate
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D07909  Erythromycin thiocyanate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Macrolides
     Erythromycin [ATC:D10AF02 J01FA01 S01AA17]
      D07909  Erythromycin thiocyanate
BRITE hierarchy
Other DBs
CAS: 
7704-67-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        54
            1   C1y C    17.3600  -16.5900
            2   C1z C    17.3600  -15.2600
            3   C1y C    16.1700  -17.2900
            4   O2a O    19.3200  -17.2900
            5   C1x C    16.1700  -14.5600
            6   O1a O    18.4100  -14.2800
            7   C1a C    18.6200  -15.6800
            8   C1y C    16.1700  -18.6200
            9   C1a C    15.1900  -16.2400
            10  C1y C    20.9300  -16.5900
            11  C1y C    16.1700  -13.1600
            12  O2a O    16.9400  -20.0200
            13  C1y C    14.9800  -19.3200
            14  C1y C    22.1200  -17.2900
            15  O2x O    20.9300  -15.2600
            16  C5x C    14.9800  -12.5300
            17  C1a C    17.3600  -12.5300
            18  C1y C    18.4100  -20.4400
            19  C7x C    13.7900  -18.6200
            20  C1a C    14.9800  -20.7200
            21  C1y C    23.2400  -16.6600
            22  O1a O    22.0500  -18.6900
            23  C1y C    22.1200  -14.5600
            24  C1y C    13.7900  -13.1600
            25  O5x O    14.9800  -11.1300
            26  C1x C    18.4100  -21.7700
            27  O2x O    19.6000  -19.7400
            28  O7x O    13.7900  -17.2900
            29  O6a O    12.7400  -19.6000
            30  C1x C    23.3100  -15.2600
            31  N1c N    24.4300  -17.3600
            32  C1a C    22.1200  -13.2300
            33  C1y C    13.7900  -14.5600
            34  C1a C    12.6700  -12.5300
            35  C1z C    19.6000  -22.4700
            36  C1y C    20.7900  -20.4400
            37  C1y C    12.6700  -16.5900
            38  C1z C    12.6700  -15.2600
            39  O1a O    14.9800  -15.2600
            40  C1y C    20.7900  -21.7700
            41  O2a O    19.6000  -23.8000
            42  C1a C    21.0700  -23.4500
            43  C1a C    21.9800  -19.7400
            44  C1b C    11.4800  -17.2900
            45  C1a C    11.4100  -15.8200
            46  O1a O    11.4100  -14.5600
            47  O1a O    21.9800  -22.4700
            48  C1a C    20.7200  -24.7800
            49  C1a C    11.4800  -18.4100
            50  C1a C    25.6900  -16.5900
            51  C1a C    24.4300  -18.6900
            52  C3b C    31.6400  -18.1300
            53  N3a N    33.0400  -18.1300
            54  S1a S    30.2400  -18.1300
BOND        55
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   31  51 1
            54   52  53 3
            55   52  54 1

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