KEGG   DRUG: Erythromycin stinoprateHelp
Entry
D07910                      Drug                                   

Name
Erythromycin stinoprate (INN);
Erysec (TN)
Formula
C40H71NO14. C5H9NO3S
Exact mass
952.5178
Mol weight
953.1849
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Cyp substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01522  CYP3A4 inhibitor
 DG01915  CYP3A5 ihibitor
Remark
ATC code: 
Chemical group: 
Activity
Antibacterial, Protein biosynthesis inhibitor
Comment
Macrolide
Target
50S ribosomal subunit
  Pathway
Ribosome
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D07910  Erythromycin stinoprate (INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D07910  Erythromycin stinoprate (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D07910  Erythromycin stinoprate (INN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   50S subunit inhibitor
    Macrolides
     Erythromycin
      D07910  Erythromycin stinoprate (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
  CYP3A4
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
  CYP3A7
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
  CYP3A
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
 CYP substrates
  CYP3A4
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
  CYP3A5
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
  CYP3A7
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
 Transporter inhibitors
  ABCB1
   Erythromycin
    D07910 Erythromycin stinoprate (INN)
  SLCO1B1
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
 Transporter substrates
  ABCC2
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
  OAT2
   Erythromycin
    D07910  Erythromycin stinoprate (INN)
BRITE hierarchy
Other DBs
CAS: 
84252-03-9
PubChem: 
LigandBox: 
KCF data Show

ATOM        65
            1   C1y C    13.4813  -14.8764
            2   C1z C    13.4813  -13.5435
            3   C1y C    12.2887  -15.5780
            4   O2a O    15.4456  -15.5780
            5   C1x C    12.2887  -12.8420
            6   O1a O    14.5336  -12.5613
            7   C1a C    14.7441  -13.9644
            8   C1y C    12.2887  -16.9109
            9   C1a C    11.3066  -14.5256
            10  C1y C    17.0592  -14.8764
            11  C1y C    12.2887  -11.4389
            12  O2a O    13.0604  -18.3139
            13  C1y C    11.0961  -17.6124
            14  C1y C    18.2518  -15.5780
            15  O2x O    17.0592  -13.5435
            16  C5x C    11.0961  -10.8075
            17  C1a C    13.4813  -10.8075
            18  C1y C    14.2536  -20.4849
            19  C7x C     9.9035  -16.9109
            20  C1a C    11.0961  -19.0155
            21  C1y C    19.3041  -14.9466
            22  O7a O    18.1816  -16.9810
            23  C1y C    18.2518  -12.8420
            24  C1y C     9.9035  -11.4389
            25  O5x O    11.0961   -9.4044
            26  C1x C    14.2536  -21.8178
            27  O2x O    15.4462  -19.7833
            28  O7x O     9.9035  -15.5780
            29  O6a O     8.8512  -17.8930
            30  C1x C    19.3742  -13.5435
            31  N1c N    20.4967  -15.6481
            32  C1a C    18.2518  -11.5090
            33  C1y C     9.9035  -12.8420
            34  C1a C     8.7810  -10.8075
            35  C1z C    15.4462  -22.5193
            36  C1y C    16.6389  -20.4849
            37  C1y C     8.7810  -14.8764
            38  C1z C     8.7810  -13.5435
            39  O1a O    11.0961  -13.5435
            40  C1y C    16.6389  -21.8178
            41  O2a O    15.4462  -23.7821
            42  C1a C    16.9195  -23.4313
            43  C1a C    17.8315  -19.7833
            44  C1b C     7.5884  -15.5780
            45  C1a C     7.5183  -14.1047
            46  O1a O     7.5183  -12.8420
            47  O1a O    17.8315  -22.5193
            48  C1a C    16.5687  -24.7642
            49  C1a C     7.5884  -16.7004
            50  C1a C    21.7595  -14.8764
            51  C7a C    19.3839  -17.7572
            52  O6a O    19.3839  -19.1572
            53  C1a C    21.7416  -16.3458
            54  C1b C    20.6084  -17.0904
            55  C1a C    21.7776  -17.8050
            56  C1b C    26.1791  -13.7540
            57  C1c C    27.3942  -14.4555
            58  S1a S    24.9641  -14.4555
            59  C6a C    28.5923  -13.7636
            60  O6a O    29.7823  -14.4506
            61  O6a O    28.5924  -12.3512
            62  N1b N    27.3943  -15.8584
            63  C5a C    28.5925  -16.5503
            64  C1a C    29.7822  -15.8634
            65  O5a O    28.5926  -17.9629
BOND        66
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   22  51 1
            54   51  52 2
            55   31  53 1
            56   51  54 1
            57   54  55 1
            58   56  57 1
            59   56  58 1
            60   57  59 1
            61   59  60 1
            62   59  61 2
            63   57  62 1 #Up
            64   62  63 1
            65   63  64 1
            66   63  65 2

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