KEGG   DRUG: FexofenadineHelp
Entry
D07958                      Drug                                   

Name
Fexofenadine (INN);
Telfast (TN)
Formula
C32H39NO4
Exact mass
501.2879
Mol weight
501.6564
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Transporter substrate
 DG01665  P-glycoprotein substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antiallergic, Histamine, H1-receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Metabolism
Transporter: SLCO1B3 [HSA:28234], SLCO1A2 [HSA:6579], SLCO2B1 [HSA:11309], ABCB1 [HSA:5243], ABCC3 [HSA:8714]
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX26 Fexofenadine
      D07958  Fexofenadine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Fexofenadine
    D07958  Fexofenadine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Fexofenadine
      D07958  Fexofenadine (INN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  ABCB1
   Fexofenadine
    D07958  Fexofenadine (INN)
  ABCC3
   Fexofenadine
    D07958  Fexofenadine (INN)
  OAT1
   Fexofenadine
    D07958  Fexofenadine (INN)
  OAT3
   Fexofenadine
    D07958  Fexofenadine (INN)
  SLCO1A2
   Fexofenadine
    D07958  Fexofenadine (INN)
  SLCO1B1
   Fexofenadine
    D07958  Fexofenadine (INN)
  SLCO1B3
   Fexofenadine
    D07958  Fexofenadine (INN)
  SLCO2B1
   Fexofenadine
    D07958  Fexofenadine (INN)
BRITE hierarchy
Other DBs
CAS: 
83799-24-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        37
            1   C8x C    16.9400  -21.1400
            2   C8x C    16.9400  -22.5400
            3   C8x C    18.1300  -23.2400
            4   C8x C    19.3900  -22.5400
            5   C8y C    19.3900  -21.1400
            6   C8x C    18.1300  -20.4400
            7   C8x C    21.8400  -22.5400
            8   C8y C    21.8400  -21.1400
            9   C1d C    20.5800  -20.4400
            10  C8x C    23.0300  -23.2400
            11  C8x C    24.2200  -22.5400
            12  C8x C    24.2200  -21.1400
            13  C8x C    23.0300  -20.4400
            14  C1y C    20.5800  -19.0400
            15  C1x C    21.8400  -18.3400
            16  C1x C    21.8400  -16.8700
            17  N1y N    20.5800  -16.1700
            18  C1x C    19.3900  -16.8700
            19  C1x C    19.3900  -18.3400
            20  O1a O    19.3900  -19.7400
            21  C1b C    20.5800  -14.7700
            22  C1b C    21.8400  -14.0700
            23  C1b C    23.0300  -14.7700
            24  C1c C    24.2200  -14.1400
            25  C8y C    25.4100  -14.7700
            26  O1a O    24.2200  -12.6700
            27  C8x C    25.4100  -16.1700
            28  C8x C    26.6000  -16.8700
            29  C8y C    27.7900  -16.1700
            30  C8x C    27.7900  -14.7700
            31  C8x C    26.6000  -14.0700
            32  C1d C    29.0500  -16.8700
            33  C6a C    30.2400  -16.2400
            34  O6a O    31.4300  -16.8700
            35  O6a O    30.2400  -14.7700
            36  C1a C    28.0700  -17.9200
            37  C1a C    30.0300  -17.9200
BOND        40
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22    9  20 1
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 1
            29   25  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   25  31 1
            35   29  32 1
            36   32  33 1
            37   33  34 1
            38   33  35 2
            39   32  36 1
            40   32  37 1

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