KEGG   DRUG: D07962Help
Entry
D07962                      Drug                                   

Name
Flecainide (INN)
Formula
C17H20F6N2O3
Exact mass
414.1378
Mol weight
414.3427
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic
Remark
Same as: 
ATC code: 
Comment
Class I antiarrhythmic agent
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
voltage-gated potassium channel (KCNH2) blocker [HSA:3757] [KO:K04905];
voltage-gated potassium channel (KCNH6) blocker [HSA:81033] [KO:K04909];
voltage-gated potassium channel (KCNH7) blocker [HSA:90134] [KO:K04910];
voltage-gated potassium channel (KCND3) blocker [HSA:3752] [KO:K04893]
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC04 Flecainide
      D07962  Flecainide (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
   K+ channel, KCND, Kv4.x (Shal)
    voltage-gated potassium channel (KCND3) [HSA:3752] [KO:K04893]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH6) [HSA:81033] [KO:K04909]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
    voltage-gated potassium channel (KCNH7) [HSA:90134] [KO:K04910]
     Flecainide [ATC:C01BC04]
      D07962  Flecainide (INN)
BRITE hierarchy
Other DBs
CAS: 
54143-55-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1x C    18.1300  -17.2900
            2   C1x C    18.1300  -18.6900
            3   N1x N    19.3900  -19.3900
            4   C1y C    20.5800  -18.6900
            5   C1x C    20.5800  -17.2900
            6   C1x C    19.3900  -16.5900
            7   C1b C    21.8400  -19.3900
            8   N1b N    23.0300  -18.6900
            9   C5a C    24.2200  -19.3900
            10  C8y C    25.4100  -18.6900
            11  O5a O    24.2200  -20.7900
            12  C8y C    26.6000  -19.3900
            13  C8x C    27.7900  -18.6900
            14  C8x C    27.7900  -17.2900
            15  C8y C    26.6000  -16.5900
            16  C8x C    25.4100  -17.2900
            17  O2a O    26.6000  -15.1900
            18  C1b C    27.8600  -14.4200
            19  C1d C    29.0500  -15.1200
            20  X   F    30.2400  -15.8200
            21  X   F    28.3500  -16.3800
            22  X   F    29.7500  -13.9300
            23  O2a O    26.6000  -20.7900
            24  C1b C    27.7900  -21.4900
            25  C1d C    28.9800  -20.7900
            26  X   F    30.1700  -20.0900
            27  X   F    29.6800  -21.9800
            28  X   F    28.2800  -19.5300
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   10  16 1
            18   15  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 1
            23   19  22 1
            24   12  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   25  27 1
            29   25  28 1

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