KEGG   DRUG: FluvastatinHelp
Entry
D07983                      Drug                                   

Name
Fluvastatin (INN);
Fluvas (TN)
Formula
C24H26FNO4
Exact mass
411.1846
Mol weight
411.4659
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
Cyp substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01643  CYP2C9 inhibitor
Unclassified
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antihyperlipidemic, HMG-CoA reductase inhibitor
Target
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase [HSA:3156] [KO:K00021]
  Pathway
Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter: SLCO1B1 [HSA:10599]
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Transporter inhibition: ABCB11 [HSA:8647]
Drug interaction
Structure map
HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA04 Fluvastatin
      D07983  Fluvastatin (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Fluvastatin
    D07983  Fluvastatin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
    Fluvastatin
     D07983  Fluvastatin (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C9
   Fluvastatin
    D07983  Fluvastatin (INN)
 CYP substrates
  CYP2C9
   Fluvastatin
    D07983  Fluvastatin (INN)
  CYP3A4
   Fluvastatin
    D07983  Fluvastatin (INN)
 Transporter inhibitors
  ABCB11
   Fluvastatin
    D07983  Fluvastatin (INN)
 Transporter substrates
  SLCO1B1
   Fluvastatin
    D07983  Fluvastatin (INN)
  SLCO1B3
   Fluvastatin
    D07983  Fluvastatin (INN)
BRITE hierarchy
Other DBs
CAS: 
93957-54-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C8y C    20.9855  -16.8573
            2   C8x C    20.9855  -18.2563
            3   C8x C    22.1746  -18.9557
            4   C8y C    23.4336  -18.2563
            5   C8x C    23.4336  -16.8573
            6   C8x C    22.1746  -16.1579
            7   X   F    19.7964  -16.1579
            8   C8y C    24.6227  -18.9557
            9   C8y C    25.1123  -20.2847
            10  C8y C    26.4413  -20.2847
            11  N4y N    26.8610  -18.9557
            12  C8y C    25.7418  -18.1164
            13  C8x C    24.4129  -21.5437
            14  C8x C    25.1123  -22.8028
            15  C8x C    26.5113  -22.8028
            16  C8x C    27.2107  -21.5437
            17  C2b C    25.7418  -16.7174
            18  C1a C    29.3091  -18.9557
            19  C1c C    28.1200  -18.2563
            20  C1a C    28.1200  -16.8573
            21  C2b C    26.9309  -16.0180
            22  C1c C    26.9309  -14.6191
            23  C1b C    28.1200  -13.9196
            24  C1c C    29.3091  -14.6191
            25  C1b C    30.4982  -13.9196
            26  C6a C    31.6873  -14.6191
            27  O6a O    32.8764  -13.9196
            28  O6a O    31.6873  -16.0180
            29  O1a O    25.7418  -13.9196
            30  O1a O    29.3091  -16.0180
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    8  12 2
            14    9  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   10  16 2
            19   12  17 1
            20   18  19 1
            21   11  19 1
            22   19  20 1
            23   17  21 2
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   26  28 2
            31   22  29 1 #Down
            32   24  30 1 #Up

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