KEGG   DRUG: D07994Help
Entry
D07994                      Drug                                   

Name
Framycetin sulfate;
Neomycin B sulfate;
Isofra (TN)
Formula
C23H46N6O13. H2SO4
Exact mass
712.2797
Mol weight
712.7222
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, aminoglycoside
Remark
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB08 Neomycin
      D07994  Framycetin sulfate
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA01 Neomycin
      D07994  Framycetin sulfate
 B BLOOD AND BLOOD FORMING ORGANS
  B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
   B05C IRRIGATING SOLUTIONS
    B05CA Antiinfectives
     B05CA09 Neomycin
      D07994  Framycetin sulfate
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX04 Neomycin
      D07994  Framycetin sulfate
  D09 MEDICATED DRESSINGS
   D09A MEDICATED DRESSINGS
    D09AA Medicated dressings with antiinfectives
     D09AA01 Framycetin
      D07994  Framycetin sulfate
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB05 Neomycin
      D07994  Framycetin sulfate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AX Other nasal preparations
     R01AX08 Framycetin
      D07994  Framycetin sulfate
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AB Antibiotics
     R02AB01 Neomycin
      D07994  Framycetin sulfate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA03 Neomycin
      D07994  Framycetin sulfate
     S01AA07 Framycetin
      D07994  Framycetin sulfate
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA07 Neomycin
      D07994  Framycetin sulfate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA01 Neomycin
      D07994  Framycetin sulfate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor [KO:K01977]
    Aminoglycosides
     Neomycin [ATC:A01AB08 A07AA01 B05CA09 D06AX04 J01GB05 R02AB01 S01AA03 S02AA07 S03AA01]
      D07994  Framycetin sulfate
BRITE hierarchy
Other DBs
CAS: 
28002-70-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        47
            1   C1y C    20.5722  -21.3409
            2   C1y C    20.5722  -22.7403
            3   C1y C    21.8317  -23.4399
            4   C1y C    23.0211  -22.7403
            5   C1y C    23.0211  -21.3409
            6   O2x O    21.8317  -20.6412
            7   O2a O    24.2106  -20.6412
            8   C1y C    26.4496  -19.5217
            9   C1y C    26.8695  -18.1923
            10  O2x O    25.7499  -17.4226
            11  C1y C    24.6304  -18.1923
            12  C1y C    25.0503  -19.5217
            13  O2a O    28.4787  -17.7724
            14  O1a O    28.8986  -20.5012
            15  C1y C    30.0880  -19.8015
            16  C1y C    31.2775  -20.5012
            17  C1x C    32.4670  -19.8015
            18  C1y C    32.4670  -18.4721
            19  C1y C    31.2775  -17.7724
            20  C1y C    30.0880  -18.4721
            21  N1a N    31.2775  -21.9006
            22  N1a N    33.6565  -17.7724
            23  O2a O    31.2775  -16.3731
            24  C1y C    32.4670  -15.6734
            25  O2x O    33.6565  -16.3731
            26  C1y C    34.7760  -15.6734
            27  C1y C    34.7760  -14.2740
            28  C1y C    33.6565  -13.5743
            29  C1y C    32.4670  -14.2740
            30  C1b C    36.0354  -16.3031
            31  N1a N    36.0354  -17.7025
            32  N1a N    31.2075  -13.5743
            33  O1a O    33.6565  -12.2449
            34  O1a O    36.0354  -13.5043
            35  C1b C    23.3010  -17.7724
            36  O1a O    27.2893  -20.6412
            37  O1a O    22.2515  -18.7520
            38  C1b C    19.4527  -20.6412
            39  O1a O    19.4527  -23.4399
            40  N1a N    24.2106  -23.4399
            41  O1a O    21.8317  -24.8393
            42  N1a N    18.1933  -21.3409
            43  S4a S    36.0434  -23.0244
            44  O1d O    36.0434  -21.6250
            45  O1d O    36.0434  -24.4238
            46  O1d O    37.4428  -23.0244
            47  O1d O    34.6440  -23.0244
BOND        49
            1    25  26 1
            2    26  27 1
            3    27  28 1
            4    28  29 1
            5    29  24 1
            6    26  30 1 #Up
            7    15  14 1 #Down
            8    30  31 1
            9     5   7 1 #Down
            10   29  32 1 #Down
            11   28  33 1 #Up
            12    1   2 1
            13   27  34 1 #Down
            14    2   3 1
            15   11  35 1 #Up
            16   12   7 1 #Down
            17    3   4 1
            18    8  36 1 #Down
            19   15  16 1
            20   35  37 1
            21   16  17 1
            22    1  38 1 #Down
            23   17  18 1
            24    2  39 1 #Down
            25   18  19 1
            26    4  40 1 #Down
            27   19  20 1
            28    3  41 1 #Up
            29   20  15 1
            30    4   5 1
            31   16  21 1 #Up
            32    8   9 1
            33   18  22 1 #Up
            34    9  10 1
            35   19  23 1 #Down
            36   20  13 1 #Up
            37   10  11 1
            38   24  23 1 #Down
            39   11  12 1
            40   12   8 1
            41    5   6 1
            42    9  13 1 #Up
            43    6   1 1
            44   24  25 1
            45   38  42 1
            46   43  44 2
            47   43  45 2
            48   43  46 1
            49   43  47 1

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