KEGG   DRUG: D07994Help
Entry
D07994                      Drug                                   

Name
Framycetin sulfate;
Neomycin B sulfate;
Isofra (TN)
Formula
C23H46N6O13. H2SO4
Exact mass
712.2797
Mol weight
712.7222
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, aminoglycoside
Remark
ATC code: 
Drug group: 
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D09 MEDICATED DRESSINGS
   D09A MEDICATED DRESSINGS
    D09AA Medicated dressings with antiinfectives
     D09AA01 Framycetin
      D07994  Framycetin sulfate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AX Other nasal preparations
     R01AX08 Framycetin
      D07994  Framycetin sulfate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA07 Framycetin
      D07994  Framycetin sulfate
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Framycetin
      D07994  Framycetin sulfate
BRITE hierarchy
Other DBs
CAS: 
28002-70-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        47
            1   C1y C    20.5722  -21.3409
            2   C1y C    20.5722  -22.7403
            3   C1y C    21.8317  -23.4399
            4   C1y C    23.0211  -22.7403
            5   C1y C    23.0211  -21.3409
            6   O2x O    21.8317  -20.6412
            7   O2a O    24.2106  -20.6412
            8   C1y C    26.4496  -19.5217
            9   C1y C    26.8695  -18.1923
            10  O2x O    25.7499  -17.4226
            11  C1y C    24.6304  -18.1923
            12  C1y C    25.0503  -19.5217
            13  O2a O    28.4787  -17.7724
            14  O1a O    28.8986  -20.5012
            15  C1y C    30.0880  -19.8015
            16  C1y C    31.2775  -20.5012
            17  C1x C    32.4670  -19.8015
            18  C1y C    32.4670  -18.4721
            19  C1y C    31.2775  -17.7724
            20  C1y C    30.0880  -18.4721
            21  N1a N    31.2775  -21.9006
            22  N1a N    33.6565  -17.7724
            23  O2a O    31.2775  -16.3731
            24  C1y C    32.4670  -15.6734
            25  O2x O    33.6565  -16.3731
            26  C1y C    34.7760  -15.6734
            27  C1y C    34.7760  -14.2740
            28  C1y C    33.6565  -13.5743
            29  C1y C    32.4670  -14.2740
            30  C1b C    36.0354  -16.3031
            31  N1a N    36.0354  -17.7025
            32  N1a N    31.2075  -13.5743
            33  O1a O    33.6565  -12.2449
            34  O1a O    36.0354  -13.5043
            35  C1b C    23.3010  -17.7724
            36  O1a O    27.2893  -20.6412
            37  O1a O    22.2515  -18.7520
            38  C1b C    19.4527  -20.6412
            39  O1a O    19.4527  -23.4399
            40  N1a N    24.2106  -23.4399
            41  O1a O    21.8317  -24.8393
            42  N1a N    18.1933  -21.3409
            43  S4a S    36.0434  -23.0244
            44  O1d O    36.0434  -21.6250
            45  O1d O    36.0434  -24.4238
            46  O1d O    37.4428  -23.0244
            47  O1d O    34.6440  -23.0244
BOND        49
            1    25  26 1
            2    26  27 1
            3    27  28 1
            4    28  29 1
            5    29  24 1
            6    26  30 1 #Up
            7    15  14 1 #Down
            8    30  31 1
            9     5   7 1 #Down
            10   29  32 1 #Down
            11   28  33 1 #Up
            12    1   2 1
            13   27  34 1 #Down
            14    2   3 1
            15   11  35 1 #Up
            16   12   7 1 #Down
            17    3   4 1
            18    8  36 1 #Down
            19   15  16 1
            20   35  37 1
            21   16  17 1
            22    1  38 1 #Down
            23   17  18 1
            24    2  39 1 #Down
            25   18  19 1
            26    4  40 1 #Down
            27   19  20 1
            28    3  41 1 #Up
            29   20  15 1
            30    4   5 1
            31   16  21 1 #Up
            32    8   9 1
            33   18  22 1 #Up
            34    9  10 1
            35   19  23 1 #Down
            36   20  13 1 #Up
            37   10  11 1
            38   24  23 1 #Down
            39   11  12 1
            40   12   8 1
            41    5   6 1
            42    9  13 1 #Up
            43    6   1 1
            44   24  25 1
            45   38  42 1
            46   43  44 2
            47   43  45 2
            48   43  46 1
            49   43  47 1

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