KEGG   DRUG: Sodium furosemideHelp
Entry
D07999                      Drug                                   

Name
Sodium furosemide;
Frosemide sodium;
Lasix (TN)
Formula
C12H10ClN2O5S. Na
Exact mass
351.9897
Mol weight
352.726
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Remark
ATC code: 
Chemical group: 
Activity
Diuretic, Na-K-Cl cotransporter inhibitor
Comment
loop diuretic
Sulufonamide derivative
Target
Na-K-Cl cotransporter 1 [HSA:6557] [KO:K14425];
Na-K-Cl cotransporter 2 [HSA:6558] [KO:K10951];
GABAA-receptor alpha [HSA:2554 2555 2556 2557 2558 2559] [KO:K05175]
  Pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Sulfonamide derivatives - overview
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D07999  Sodium furosemide
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Furosemide
    D07999  Sodium furosemide
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor alpha
     Furosemide
      D07999  Sodium furosemide
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Furosemide
      D07999  Sodium furosemide
    SLC12A2
     Furosemide
      D07999  Sodium furosemide
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  ABCC4
   Furosemide
    D07999  Sodium furosemide
  OAT1
   Furosemide
    D07999  Sodium furosemide
  OAT3
   Furosemide
    D07999  Sodium furosemide
BRITE hierarchy
Other DBs
CAS: 
41733-55-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    25.8300  -16.8700
            2   C8y C    24.5700  -17.5700
            3   C8x C    27.0200  -17.5700
            4   C6a C    25.8300  -15.4700
            5   C8x C    24.5700  -18.9700
            6   N1b N    23.3800  -16.8700
            7   C8y C    27.0200  -18.9700
            8   O6a O    24.6400  -14.7700
            9   O6a O    27.0200  -14.7700 #-
            10  C8y C    25.8300  -19.6700
            11  C1b C    22.1900  -17.5700
            12  S4a S    28.2100  -19.6700
            13  X   Cl   25.8300  -21.0700
            14  C8y C    21.0000  -16.8000
            15  N1a N    29.4700  -20.3700
            16  O3c O    27.5100  -20.8600
            17  O3c O    28.9800  -18.4800
            18  O2x O    21.0000  -15.4000
            19  C8x C    19.6700  -14.9800
            20  C8x C    18.8300  -16.1000
            21  C8x C    19.6700  -17.2900
            22  Z   Na   30.0300  -14.5600 #+
BOND        22
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2

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