KEGG   DRUG: Sodium furosemideHelp
Entry
D07999                      Drug                                   

Name
Sodium furosemide;
Frosemide sodium;
Lasix (TN)
Formula
C12H10ClN2O5S. Na
Exact mass
351.9897
Mol weight
352.726
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Remark
ATC code: C03CA01
Chemical structure group: DG00272
Product (DG00272): D00331<JP/US>
Efficacy
Diuretic, Na-K-Cl cotransporter inhibitor
Comment
loop diuretic
Sulufonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D07999  Sodium furosemide
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Furosemide
    D07999  Sodium furosemide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D07999  Sodium furosemide
    SLC12A2 (NKCC1)
     D07999  Sodium furosemide
BRITE hierarchy
Other DBs
CAS: 41733-55-5
PubChem: 96024692
LigandBox: D07999
NIKKAJI: J278.262F
KCF data Show

ATOM        22
            1   C8y C    25.8300  -16.8700
            2   C8y C    24.5700  -17.5700
            3   C8x C    27.0200  -17.5700
            4   C6a C    25.8300  -15.4700
            5   C8x C    24.5700  -18.9700
            6   N1b N    23.3800  -16.8700
            7   C8y C    27.0200  -18.9700
            8   O6a O    24.6400  -14.7700
            9   O6a O    27.0200  -14.7700 #-
            10  C8y C    25.8300  -19.6700
            11  C1b C    22.1900  -17.5700
            12  S4a S    28.2100  -19.6700
            13  X   Cl   25.8300  -21.0700
            14  C8y C    21.0000  -16.8000
            15  N1a N    29.4700  -20.3700
            16  O3c O    27.5100  -20.8600
            17  O3c O    28.9800  -18.4800
            18  O2x O    21.0000  -15.4000
            19  C8x C    19.6700  -14.9800
            20  C8x C    18.8300  -16.1000
            21  C8x C    19.6700  -17.2900
            22  Z   Na   30.0300  -14.5600 #+
BOND        22
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2

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