KEGG   DRUG: D08001Help
Entry
D08001                      Drug                                   

Name
Furosemide diolamine;
Furosemide diethanolamine salt;
Nuriban (TN)
Formula
C12H11ClN2O5S. C4H11NO2
Exact mass
435.0867
Mol weight
435.8798
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic, loop
Remark
ATC code: 
Drug group: 
Comment
loop diuretic
Target
Na-K-Cl cotransporter 1 inhibitor [HSA:6557] [KO:K14425];
Na-K-Cl cotransporter 2 inhibitor [HSA:6558] [KO:K10951];
GABAA-receptor alpha antagonist [HSA:2554 2555 2556 2557 2558 2559] [KO:K05175]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Sulfonamide derivatives - overview
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D08001  Furosemide diolamine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor alpha
     Furosemide
      D08001  Furosemide diolamine
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Furosemide
      D08001  Furosemide diolamine
    SLC12A2
     Furosemide
      D08001  Furosemide diolamine
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        28
            1   C8y C    20.2300  -16.8700
            2   C8y C    18.9700  -17.5700
            3   C8x C    21.4200  -17.5700
            4   C6a C    20.2300  -15.4700
            5   C8x C    18.9700  -18.9700
            6   N1b N    17.7800  -16.8700
            7   C8y C    21.4200  -18.9700
            8   O6a O    19.0400  -14.7700
            9   O6a O    21.4200  -14.7700
            10  C8y C    20.2300  -19.6700
            11  C1b C    16.5900  -17.5700
            12  S4a S    22.6100  -19.6700
            13  X   Cl   20.2300  -21.0700
            14  C8y C    15.4000  -16.8000
            15  N1a N    23.8700  -20.3700
            16  O3c O    21.9100  -20.8600
            17  O3c O    23.3800  -18.4800
            18  O2x O    15.4000  -15.4000
            19  C8x C    14.0700  -14.9800
            20  C8x C    13.2300  -16.1000
            21  C8x C    14.0700  -17.2900
            22  O1a O    28.1400  -18.6200
            23  C1b C    29.3524  -17.9200
            24  C1b C    30.5649  -18.6200
            25  N1b N    31.7773  -17.9200
            26  C1b C    32.9897  -18.6200
            27  C1b C    34.2022  -17.9200
            28  O1a O    35.4146  -18.6200
BOND        28
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   27  28 1

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