KEGG   DRUG: D08031Help
Entry
D08031                      Drug                                   

Name
Guanfacine (INN);
Estulic (TN)
Formula
C9H9Cl2N3O
Exact mass
245.0123
Mol weight
246.0933
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Same as: 
ATC code: 
Drug group: 
Target
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AC Imidazoline receptor agonists
     C02AC02 Guanfacine
      D08031  Guanfacine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Guanfacine
    D08031  Guanfacine (INN)
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non- amphetamines
   Guanfacine
    D08031  Guanfacine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha2-adrenergic receptor
     Guanfacine
      D08031  Guanfacine (INN)
BRITE hierarchy
Other DBs
CAS: 
29110-47-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   C8y C    25.9700  -17.9200
            2   C1b C    24.7800  -17.2200
            3   C8y C    25.9700  -19.3200
            4   C8y C    27.2300  -17.2200
            5   C5a C    23.5900  -17.9200
            6   C8x C    27.2300  -20.0200
            7   X   Cl   24.7800  -20.0200
            8   C8x C    28.4200  -17.9200
            9   X   Cl   27.2300  -15.8200
            10  N1b N    22.3300  -17.2200
            11  O5a O    23.5900  -19.3200
            12  C8x C    28.4200  -19.3200
            13  C2c C    21.1400  -17.9200
            14  N1a N    19.9500  -17.2200
            15  N2a N    21.1400  -19.3200
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 2
            15    8  12 1

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