KEGG   DRUG: D08035Help
Entry
D08035                      Drug                                   

Name
Haloperidol lactate;
Haldol (TN)
Product
  Generic
Formula
C21H23ClFNO2. C3H6O3
Exact mass
465.1718
Mol weight
465.9422
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic, Antipsychotic
Remark
ATC code: 
Drug group: 
Comment
Butyrophenone derivatives
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
Neuroactive ligand-receptor interaction
Gap junction
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Butyrophenones
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD01 Haloperidol
      D08035  Haloperidol lactate
USP drug classification [BR:br08302]
 Antipsychotics
  1st Generation/Typical
   Haloperidol
    D08035  Haloperidol lactate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Haloperidol
      D08035  Haloperidol lactate
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Haloperidol
    D08035  Haloperidol lactate
  CYP2D6
   Haloperidol
    D08035  Haloperidol lactate
  CYP3A4
   Haloperidol
    D08035  Haloperidol lactate
  CYP3A5
   Haloperidol
    D08035  Haloperidol lactate
  CYP3A7
   Haloperidol
    D08035  Haloperidol lactate
Neuropsychiatric agents [br08363.html]
 Antipsychotics
  D08035
BRITE hierarchy
Other DBs
CAS: 
53515-91-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C1b C     7.9175  -18.0667
            2   C1b C     9.1779  -17.3664
            3   C1b C    10.4384  -18.0667
            4   N1y N    11.6288  -17.3664
            5   C1x C    11.6288  -15.9659
            6   C1x C    12.8192  -18.0667
            7   C1x C    12.8192  -15.2657
            8   C1x C    14.0096  -17.3664
            9   C1z C    14.0096  -15.9659
            10  C8y C    15.2000  -15.2657
            11  C8x C    15.2000  -13.9352
            12  C8x C    16.4604  -15.9659
            13  C8x C    16.4604  -13.2350
            14  C8x C    17.6508  -15.2657
            15  C8y C    17.6508  -13.9352
            16  X   Cl   18.8413  -13.2350
            17  C5a C     6.7271  -17.3664
            18  C8y C     5.5367  -18.0667
            19  O5a O     6.7271  -15.8959
            20  C8x C     5.5367  -19.4671
            21  C8x C     4.2762  -20.1674
            22  C8y C     3.0158  -19.4671
            23  C8x C     3.0158  -18.0667
            24  C8x C     4.2762  -17.3664
            25  X   F     1.8254  -20.1674
            26  O1a O    15.2000  -16.6662
            27  C6a C    21.2800  -18.3400
            28  O6a O    22.4924  -19.0400
            29  C1c C    20.0676  -19.0400
            30  O6a O    21.2800  -16.9400
            31  O1a O    18.8721  -18.3496
            32  C1a C    20.0675  -20.4398
BOND        33
            1     9  10 1
            2    10  11 1
            3    10  12 2
            4    11  13 2
            5    12  14 1
            6    13  15 1
            7    15  16 1
            8     8   9 1
            9    14  15 2
            10    1  17 1
            11    1   2 1
            12   17  18 1
            13    2   3 1
            14   17  19 2
            15    3   4 1
            16    4   5 1
            17    4   6 1
            18    5   7 1
            19    6   8 1
            20   18  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   24  18 2
            26    7   9 1
            27   22  25 1
            28    9  26 1
            29   27  28 1
            30   27  29 1
            31   27  30 2
            32   29  31 1
            33   29  32 1

» Japanese version   » Back

DBGET integrated database retrieval system