KEGG   DRUG: D08035Help
Entry
D08035                      Drug                                   

Name
Haloperidol lactate;
Haldol (TN)
Product
  Generic
Formula
C21H23ClFNO2. C3H6O3
Exact mass
465.1718
Mol weight
465.9422
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic, Antipsychotic
Remark
ATC code: 
Drug group: 
Comment
Butyrophenone derivatives
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Butyrophenones
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD01 Haloperidol
      D08035  Haloperidol lactate
USP drug classification [BR:br08302]
 Antipsychotics
  1st Generation/Typical
   Haloperidol
    D08035  Haloperidol lactate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Haloperidol
      D08035  Haloperidol lactate
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Haloperidol
    D08035  Haloperidol lactate
  CYP2D6
   Haloperidol
    D08035  Haloperidol lactate
  CYP3A4
   Haloperidol
    D08035  Haloperidol lactate
  CYP3A5
   Haloperidol
    D08035  Haloperidol lactate
  CYP3A7
   Haloperidol
    D08035  Haloperidol lactate
BRITE hierarchy
Other DBs
CAS: 
53515-91-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C1b C     7.9175  -18.0667
            2   C1b C     9.1779  -17.3664
            3   C1b C    10.4384  -18.0667
            4   N1y N    11.6288  -17.3664
            5   C1x C    11.6288  -15.9659
            6   C1x C    12.8192  -18.0667
            7   C1x C    12.8192  -15.2657
            8   C1x C    14.0096  -17.3664
            9   C1z C    14.0096  -15.9659
            10  C8y C    15.2000  -15.2657
            11  C8x C    15.2000  -13.9352
            12  C8x C    16.4604  -15.9659
            13  C8x C    16.4604  -13.2350
            14  C8x C    17.6508  -15.2657
            15  C8y C    17.6508  -13.9352
            16  X   Cl   18.8413  -13.2350
            17  C5a C     6.7271  -17.3664
            18  C8y C     5.5367  -18.0667
            19  O5a O     6.7271  -15.8959
            20  C8x C     5.5367  -19.4671
            21  C8x C     4.2762  -20.1674
            22  C8y C     3.0158  -19.4671
            23  C8x C     3.0158  -18.0667
            24  C8x C     4.2762  -17.3664
            25  X   F     1.8254  -20.1674
            26  O1a O    15.2000  -16.6662
            27  C6a C    21.2800  -18.3400
            28  O6a O    22.4924  -19.0400
            29  C1c C    20.0676  -19.0400
            30  O6a O    21.2800  -16.9400
            31  O1a O    18.8721  -18.3496
            32  C1a C    20.0675  -20.4398
BOND        33
            1     9  10 1
            2    10  11 1
            3    10  12 2
            4    11  13 2
            5    12  14 1
            6    13  15 1
            7    15  16 1
            8     8   9 1
            9    14  15 2
            10    1  17 1
            11    1   2 1
            12   17  18 1
            13    2   3 1
            14   17  19 2
            15    3   4 1
            16    4   5 1
            17    4   6 1
            18    5   7 1
            19    6   8 1
            20   18  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   24  18 2
            26    7   9 1
            27   22  25 1
            28    9  26 1
            29   27  28 1
            30   27  29 1
            31   27  30 2
            32   29  31 1
            33   29  32 1

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