KEGG   DRUG: D08048Help
Entry
D08048                      Drug                                   

Name
Hydroquinidine (DCF);
Dihydroquinidine
Formula
C20H26N2O2
Exact mass
326.1994
Mol weight
326.4326
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic
Remark
Same as: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Hydroquinidine
      D08048  Hydroquinidine (DCF)
    voltage-gated sodium channel (SCN2A)
     Hydroquinidine
      D08048  Hydroquinidine (DCF)
    voltage-gated sodium channel (SCN3A)
     Hydroquinidine
      D08048  Hydroquinidine (DCF)
    voltage-gated sodium channel (SCN4A)
     Hydroquinidine
      D08048  Hydroquinidine (DCF)
    voltage-gated sodium channel (SCN5A)
     Hydroquinidine
      D08048  Hydroquinidine (DCF)
    voltage-gated sodium channel (SCN8A)
     Hydroquinidine
      D08048  Hydroquinidine (DCF)
    voltage-gated sodium channel (SCN9A)
     Hydroquinidine
      D08048  Hydroquinidine (DCF)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tryptophan and anthranillic acid
   Quinoline alkaloids
    D08048  Hydroquinidine
BRITE hierarchy
Other DBs
CAS: 
1435-55-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    20.8600  -20.8600
            2   C8x C    20.8600  -22.2600
            3   C8x C    22.0500  -22.9600
            4   C8x C    22.0500  -20.1600
            5   C8y C    23.3100  -20.8600
            6   C8y C    23.3100  -22.2600
            7   N5x N    24.5000  -22.9600
            8   C8x C    25.6900  -22.3300
            9   C8x C    25.6900  -20.8600
            10  C8y C    24.5000  -20.1600
            11  C1c C    24.5000  -18.7600
            12  C1y C    25.6900  -18.0600
            13  O2a O    19.6700  -20.1600
            14  O1a O    23.3100  -18.0600
            15  N1y N    27.1600  -17.2200
            16  C1x C    27.1600  -15.9600
            17  C1x C    28.7000  -18.0600
            18  C1y C    26.3900  -16.2400
            19  C1y C    26.4600  -15.2600
            20  C1x C    28.0000  -16.9400
            21  C1b C    25.9000  -13.9300
            22  C1x C    24.9900  -17.0800
            23  C1a C    26.7400  -12.8800
            24  C1a C    19.6700  -18.7600
BOND        27
            1    11  14 1 #Down
            2     9  10 2
            3    10   5 1
            4    10  11 1
            5     1   2 1
            6    12  15 1
            7    11  12 1
            8     2   3 2
            9     3   6 1
            10    5   4 1
            11    4   1 2
            12    5   6 2
            13    6   7 1
            14   15  16 1
            15   15  17 1
            16   22  18 1
            17   16  19 1
            18   17  20 1
            19   19  21 1 #Up
            20   18  19 1
            21   18  20 1
            22    1  13 1
            23   12  22 1
            24    7   8 2
            25   21  23 1
            26   13  24 1
            27    8   9 1

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