KEGG   DRUG: PenbutololHelp
Entry
D08074                      Drug                                   

Name
Penbutolol (INN)
Formula
C18H29NO2
Exact mass
291.2198
Mol weight
291.4284
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, beta-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA23 Penbutolol
      D08074  Penbutolol (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Penbutolol
    D08074  Penbutolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Penbutolol
      D08074  Penbutolol (INN)
    beta2-adrenergic receptor
     Penbutolol
      D08074  Penbutolol (INN)
    beta3-adrenergic receptor
     Penbutolol
      D08074  Penbutolol (INN)
BRITE hierarchy
Other DBs
CAS: 
38363-40-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   O2a O    16.8811  -17.8720
            2   C1b C    18.0682  -17.1737
            3   C1c C    19.3252  -17.8720
            4   C1b C    20.5123  -17.1737
            5   O1a O    19.3252  -19.2686
            6   N1b N    21.7693  -17.8720
            7   C1d C    22.9565  -17.1737
            8   C1a C    24.1670  -17.8593
            9   C1a C    22.9448  -15.7501
            10  C1a C    24.1689  -16.4737
            11  C8y C    16.8811  -19.2720
            12  C8y C    15.6700  -19.9711
            13  C8x C    15.6700  -21.3711
            14  C8x C    16.8824  -22.0712
            15  C8x C    18.0935  -21.3720
            16  C8x C    18.0935  -19.9720
            17  C1y C    14.4561  -19.2703
            18  C1x C    14.5240  -17.8504
            19  C1x C    13.2006  -17.3462
            20  C1x C    12.3121  -18.4489
            21  C1x C    13.0864  -19.6347
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 1 #Down
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     7   9 1
            9     7  10 1
            10    1  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   12  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   17  21 1

» Japanese version   » Back

DBGET integrated database retrieval system